Subcutaneous administration of desoxycorticosterone pivalate for the treatment of canine hypoadrenocorticism

M. D. McCabe, Edward C Feldman, R. C. Lynn, Philip H Kass

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10 Citations (Scopus)

Abstract

Twelve dogs with hypoadrenocorticism were treated with subcutaneous desoxycorticosterone pivalate (DOCP). Eight of these dogs were recently diagnosed and had not yet been treated. Four dogs previously had been diagnosed and treated (three with intramuscular DOCP, one with oral fludrocortisone acetate). History, physical examination, serum electrolytes, and blood urea nitrogen (BUN) were evaluated. Desoxycorticosterone pivalate (2.2 mg/kg body weight) was administered every 25 days. On day 0, recently diagnosed dogs had a median serum sodium concentration of 131.5 mEq/L, median serum potassium concentration of 6.6 mEq/L, and median BUN of 41.5 mg/dl. All subsequent median serum electrolyte and BUN concentrations were normal. All previously treated dogs had normal blood values which were maintained throughout the study.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalJournal of the American Animal Hospital Association
Volume31
Issue number2
StatePublished - 1995

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desoxycorticosterone
hypoadrenocorticism
subcutaneous injection
Canidae
blood serum
Dogs
Blood Urea Nitrogen
urea nitrogen
dogs
blood
Serum
Electrolytes
electrolytes
clinical examination
Physical Examination
mouth
Potassium
Reference Values
History
Sodium

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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abstract = "Twelve dogs with hypoadrenocorticism were treated with subcutaneous desoxycorticosterone pivalate (DOCP). Eight of these dogs were recently diagnosed and had not yet been treated. Four dogs previously had been diagnosed and treated (three with intramuscular DOCP, one with oral fludrocortisone acetate). History, physical examination, serum electrolytes, and blood urea nitrogen (BUN) were evaluated. Desoxycorticosterone pivalate (2.2 mg/kg body weight) was administered every 25 days. On day 0, recently diagnosed dogs had a median serum sodium concentration of 131.5 mEq/L, median serum potassium concentration of 6.6 mEq/L, and median BUN of 41.5 mg/dl. All subsequent median serum electrolyte and BUN concentrations were normal. All previously treated dogs had normal blood values which were maintained throughout the study.",
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AU - Kass, Philip H

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