Subcortical hyperintensities on MRI and activities of daily living in geriatric depression

Deborah Cahn-Weiner, Paul F. Malloy, Stephen Salloway, Jeffrey Rogg, Eileen Gillard, Robert Kohn, Glenn Tung, Emily D. Richardson, Robert Westlake

Research output: Contribution to journalArticle

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Abstract

Data from 30 elderly inpatients with major depression were analyzed to explore the relationship between subcortical hyperintensities (SH) on MRI and activities of daily living (ADLs). A comparison of subjects based on a median split of the severity of SH revealed that subjects with greater SH performed worse on both instrumental and physical ADLs. A hierarchical multiple regression revealed that age, depression severity, neuropsychological test performance, and SH variables accounted for a total of 53% of the variance in ADL functioning. Severity of SH accounted for an additional 18% of the variance over and above the other three variables. Results suggest that severity of subcortical disease measured by MRI improves prediction of functional impairment in elderly individuals.

Original languageEnglish (US)
Pages (from-to)404-411
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Cahn-Weiner, D., Malloy, P. F., Salloway, S., Rogg, J., Gillard, E., Kohn, R., Tung, G., Richardson, E. D., & Westlake, R. (1996). Subcortical hyperintensities on MRI and activities of daily living in geriatric depression. Journal of Neuropsychiatry and Clinical Neurosciences, 8(4), 404-411. https://doi.org/10.1176/jnp.8.4.404