Subconcussive head impact exposure and white matter tract changes over a single season of youth football

Naeim Bahrami, Dev Sharma, Scott Rosenthal, Elizabeth M. Davenport, Jillian E. Urban, Benjamin Wagner, Youngkyoo Jung, Christopher G. Vaughan, Gerard A. Gioia, Joel D. Stitzel, Christopher T. Whitlow, Joseph A. Maldjian

Research output: Contribution to journalArticle

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Abstract

Purpose: To examine the effects of subconcussive impacts resulting from a single season of youth (age range, 8-13 years) football on changes in specific white matter (WM) tracts as detected with diffusion-tensor imaging in the absence of clinically diagnosed concussions. Materials and Methods: Head impact data were recorded by using the Head Impact Telemetry system and quantified as the combinedprobability risk-weighted cumulative exposure (RWEcp). Twenty-five male participants were evaluated for seasonal fractional anisotropy (FA) changes in specific WM tracts: The inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus, and superior longitudinal fasciculus (SLF). Fiber tracts were segmented into a central core and two fiber terminals. The relationship between seasonal FA change in the whole fiber, central core, and the fiber terminals with RWEcp was also investigated. Linear regression analysis was conducted to determine the association between RWEcp and change in fiber tract FA during the season. Results: There were statistically significant linear relationships between RWEcp and decreased FA in the whole (R2 = 0.433; P = .003), core (R2 = 0.3649; P = .007), and terminals (R2 = 0.5666; P , .001) of left IFOF. A trend toward statistical significance (P = .08) in right SLF was observed. A statistically significant correlation between decrease in FA of the right SLF terminal and RWECP was also observed (R2 = 0.2893; P = .028). Conclusion: This study found a statistically significant relationship between head impact exposure and change of FA value of whole, core, and terminals of left IFOF and right SLF's terminals where WM and gray matter intersect, in the absence of a clinically diagnosed concussion.

Original languageEnglish (US)
Pages (from-to)919-926
Number of pages8
JournalRADIOLOGY
Volume281
Issue number3
DOIs
StatePublished - Dec 2016
Externally publishedYes

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Football
Anisotropy
Head
Telemetry
Diffusion Tensor Imaging
White Matter
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Bahrami, N., Sharma, D., Rosenthal, S., Davenport, E. M., Urban, J. E., Wagner, B., ... Maldjian, J. A. (2016). Subconcussive head impact exposure and white matter tract changes over a single season of youth football. RADIOLOGY, 281(3), 919-926. https://doi.org/10.1148/radiol.2016160564

Subconcussive head impact exposure and white matter tract changes over a single season of youth football. / Bahrami, Naeim; Sharma, Dev; Rosenthal, Scott; Davenport, Elizabeth M.; Urban, Jillian E.; Wagner, Benjamin; Jung, Youngkyoo; Vaughan, Christopher G.; Gioia, Gerard A.; Stitzel, Joel D.; Whitlow, Christopher T.; Maldjian, Joseph A.

In: RADIOLOGY, Vol. 281, No. 3, 12.2016, p. 919-926.

Research output: Contribution to journalArticle

Bahrami, N, Sharma, D, Rosenthal, S, Davenport, EM, Urban, JE, Wagner, B, Jung, Y, Vaughan, CG, Gioia, GA, Stitzel, JD, Whitlow, CT & Maldjian, JA 2016, 'Subconcussive head impact exposure and white matter tract changes over a single season of youth football', RADIOLOGY, vol. 281, no. 3, pp. 919-926. https://doi.org/10.1148/radiol.2016160564
Bahrami N, Sharma D, Rosenthal S, Davenport EM, Urban JE, Wagner B et al. Subconcussive head impact exposure and white matter tract changes over a single season of youth football. RADIOLOGY. 2016 Dec;281(3):919-926. https://doi.org/10.1148/radiol.2016160564
Bahrami, Naeim ; Sharma, Dev ; Rosenthal, Scott ; Davenport, Elizabeth M. ; Urban, Jillian E. ; Wagner, Benjamin ; Jung, Youngkyoo ; Vaughan, Christopher G. ; Gioia, Gerard A. ; Stitzel, Joel D. ; Whitlow, Christopher T. ; Maldjian, Joseph A. / Subconcussive head impact exposure and white matter tract changes over a single season of youth football. In: RADIOLOGY. 2016 ; Vol. 281, No. 3. pp. 919-926.
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AU - Urban, Jillian E.

AU - Wagner, Benjamin

AU - Jung, Youngkyoo

AU - Vaughan, Christopher G.

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AU - Stitzel, Joel D.

AU - Whitlow, Christopher T.

AU - Maldjian, Joseph A.

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N2 - Purpose: To examine the effects of subconcussive impacts resulting from a single season of youth (age range, 8-13 years) football on changes in specific white matter (WM) tracts as detected with diffusion-tensor imaging in the absence of clinically diagnosed concussions. Materials and Methods: Head impact data were recorded by using the Head Impact Telemetry system and quantified as the combinedprobability risk-weighted cumulative exposure (RWEcp). Twenty-five male participants were evaluated for seasonal fractional anisotropy (FA) changes in specific WM tracts: The inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus, and superior longitudinal fasciculus (SLF). Fiber tracts were segmented into a central core and two fiber terminals. The relationship between seasonal FA change in the whole fiber, central core, and the fiber terminals with RWEcp was also investigated. Linear regression analysis was conducted to determine the association between RWEcp and change in fiber tract FA during the season. Results: There were statistically significant linear relationships between RWEcp and decreased FA in the whole (R2 = 0.433; P = .003), core (R2 = 0.3649; P = .007), and terminals (R2 = 0.5666; P , .001) of left IFOF. A trend toward statistical significance (P = .08) in right SLF was observed. A statistically significant correlation between decrease in FA of the right SLF terminal and RWECP was also observed (R2 = 0.2893; P = .028). Conclusion: This study found a statistically significant relationship between head impact exposure and change of FA value of whole, core, and terminals of left IFOF and right SLF's terminals where WM and gray matter intersect, in the absence of a clinically diagnosed concussion.

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