Subcellular distribution, and physical and immunological properties of hepathic alanine: Glyoxylate aminotransferase isoenzymes in different mammalian species

Yoshikazu Takada, Tomoo Noguchi

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

1. 1. Subcellular distribution, and physical and immunological properties of hepatic alanine: glyoxylate aminotransferase isoenzymes 1 and 2 were examined with ten different mammalian species. 2. 2. Intracellular organelles containing isoenzyme 1 varied from species to species; isoenzyme 1 was located in the peroxisomes, mitochondria or both organelles. In contrast, isoenzyme 2 was found only in the mitochondria but not in the peroxisomes. 3. 3. In any species, isoenzyme 1 had molecular weight of approx. 80,000 with two identical subunits, and isoenzyme 2 approx. 200,000 with four identical subunits. 4. 4. In any species, an immunological cross-reactivity was observed among isoenzymes 1 and among isoenzymes 2 but did not between isoenzymes 1 and isoenzymes 2.

Original languageEnglish (US)
Pages (from-to)597-604
Number of pages8
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume72
Issue number4
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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