Sub-second dopamine detection in human striatum

Kenneth T. Kishida, Stefan G. Sandberg, Terry Lohrenz, Youssef G. Comair, Ignacio Sáez, Paul E.M. Phillips, P. Read Montague

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decision-making tasks.

Original languageEnglish (US)
Article numbere23291
JournalPloS one
Volume6
Issue number8
DOIs
StatePublished - Aug 10 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Kishida, K. T., Sandberg, S. G., Lohrenz, T., Comair, Y. G., Sáez, I., Phillips, P. E. M., & Montague, P. R. (2011). Sub-second dopamine detection in human striatum. PloS one, 6(8), [e23291]. https://doi.org/10.1371/journal.pone.0023291