Sub-second dopamine detection in human striatum

Kenneth T. Kishida, Stefan G. Sandberg, Terry Lohrenz, Youssef G. Comair, Ignacio Sáez, Paul E.M. Phillips, P. Read Montague

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decision-making tasks.

Original languageEnglish (US)
Article numbere23291
JournalPloS one
Volume6
Issue number8
DOIs
StatePublished - Aug 10 2011
Externally publishedYes

Fingerprint

dopamine
Dopamine
electrodes
Electrodes
Brain
brain
Surgery
surgery
Caudate Nucleus
Microelectrodes
Cyclic voltammetry
Rats
decision making
Rodentia
Decision Making
Animals
rodents
Decision making
Technology
rats

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Kishida, K. T., Sandberg, S. G., Lohrenz, T., Comair, Y. G., Sáez, I., Phillips, P. E. M., & Montague, P. R. (2011). Sub-second dopamine detection in human striatum. PloS one, 6(8), [e23291]. https://doi.org/10.1371/journal.pone.0023291

Sub-second dopamine detection in human striatum. / Kishida, Kenneth T.; Sandberg, Stefan G.; Lohrenz, Terry; Comair, Youssef G.; Sáez, Ignacio; Phillips, Paul E.M.; Montague, P. Read.

In: PloS one, Vol. 6, No. 8, e23291, 10.08.2011.

Research output: Contribution to journalArticle

Kishida, KT, Sandberg, SG, Lohrenz, T, Comair, YG, Sáez, I, Phillips, PEM & Montague, PR 2011, 'Sub-second dopamine detection in human striatum', PloS one, vol. 6, no. 8, e23291. https://doi.org/10.1371/journal.pone.0023291
Kishida KT, Sandberg SG, Lohrenz T, Comair YG, Sáez I, Phillips PEM et al. Sub-second dopamine detection in human striatum. PloS one. 2011 Aug 10;6(8). e23291. https://doi.org/10.1371/journal.pone.0023291
Kishida, Kenneth T. ; Sandberg, Stefan G. ; Lohrenz, Terry ; Comair, Youssef G. ; Sáez, Ignacio ; Phillips, Paul E.M. ; Montague, P. Read. / Sub-second dopamine detection in human striatum. In: PloS one. 2011 ; Vol. 6, No. 8.
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