Abstract
Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decision-making tasks.
| Original language | English (US) |
|---|---|
| Article number | e23291 |
| Journal | PloS one |
| Volume | 6 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 10 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
- General
Cite this
Sub-second dopamine detection in human striatum. / Kishida, Kenneth T.; Sandberg, Stefan G.; Lohrenz, Terry; Comair, Youssef G.; Sáez, Ignacio; Phillips, Paul E.M.; Montague, P. Read.
In: PloS one, Vol. 6, No. 8, e23291, 10.08.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sub-second dopamine detection in human striatum
AU - Kishida, Kenneth T.
AU - Sandberg, Stefan G.
AU - Lohrenz, Terry
AU - Comair, Youssef G.
AU - Sáez, Ignacio
AU - Phillips, Paul E.M.
AU - Montague, P. Read
PY - 2011/8/10
Y1 - 2011/8/10
N2 - Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decision-making tasks.
AB - Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decision-making tasks.
UR - http://www.scopus.com/inward/record.url?scp=79961161831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961161831&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0023291
DO - 10.1371/journal.pone.0023291
M3 - Article
C2 - 21829726
AN - SCOPUS:79961161831
VL - 6
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 8
M1 - e23291
ER -