Study of thymic factors. II. Failure of thymosin to alter the natural history of NZB and NZB/NZW mice.

M. Eric Gershwin, A. D. Steinberg, A. Ahmed, C. Derkay

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The effects of daily injections of thymosin, bovine fraction V, on the natural history of NZB and NZB/NZW F1 mice were investigated. With the use of several dose schedules, no significant differences were discovered in treated versus control groups when survival, autoantibodies, and mitogen responsiveness were compared. These results provide further evidence that thymosin may have little or no role in the treatment of the autoimmune disease of New Zealand mice. More encouraging research in thymic extracts and their measurement is necessary before clinical trials in SLE are considered.

Original languageEnglish (US)
Pages (from-to)862-866
Number of pages5
JournalArthritis and Rheumatism
Volume19
Issue number5
StatePublished - Sep 1976

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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