Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors

Jacquelyn Gervay-Hague, Terrence M. Flaherty, Daniel Holmes

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

β-C-Glycoside sulfoxides and sulfones were prepared by radical addition of thiol acetic acid to exocyclic glycals followed by deacetylation, S-alkylation, and selective oxidation. These compounds are representative examples of a new class of molecules designed to be glycosyl transferase inhibitors.

Original languageEnglish (US)
Pages (from-to)16355-16364
Number of pages10
JournalTetrahedron
Volume53
Issue number48
DOIs
StatePublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Fingerprint Dive into the research topics of 'Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors'. Together they form a unique fingerprint.

  • Cite this