Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors

Jacquelyn Gervay-Hague; Terrence M. Flaherty; Daniel Holmes

doi:10.1016/S0040-4020(97)01021-1

Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors

Jacquelyn Gervay-Hague, Terrence M. Flaherty, Daniel Holmes

Research output: Contribution to journal › Article

55 Scopus citations

Abstract

β-C-Glycoside sulfoxides and sulfones were prepared by radical addition of thiol acetic acid to exocyclic glycals followed by deacetylation, S-alkylation, and selective oxidation. These compounds are representative examples of a new class of molecules designed to be glycosyl transferase inhibitors.

Original language	English (US)
Pages (from-to)	16355-16364
Number of pages	10
Journal	Tetrahedron
Volume	53
Issue number	48
DOIs	https://doi.org/10.1016/S0040-4020(97)01021-1
State	Published - Dec 1 1997
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/S0040-4020(97)01021-1

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Gervay-Hague, J., Flaherty, T. M., & Holmes, D. (1997). Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors. Tetrahedron, 53(48), 16355-16364. https://doi.org/10.1016/S0040-4020(97)01021-1

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abstract = "β-C-Glycoside sulfoxides and sulfones were prepared by radical addition of thiol acetic acid to exocyclic glycals followed by deacetylation, S-alkylation, and selective oxidation. These compounds are representative examples of a new class of molecules designed to be glycosyl transferase inhibitors.",

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