Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors

Jacquelyn Gervay-Hague, Terrence M. Flaherty, Daniel Holmes

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

β-C-Glycoside sulfoxides and sulfones were prepared by radical addition of thiol acetic acid to exocyclic glycals followed by deacetylation, S-alkylation, and selective oxidation. These compounds are representative examples of a new class of molecules designed to be glycosyl transferase inhibitors.

Original languageEnglish (US)
Pages (from-to)16355-16364
Number of pages10
JournalTetrahedron
Volume53
Issue number48
DOIs
StatePublished - Dec 1 1997
Externally publishedYes

Fingerprint

Sulfoxides
Sulfones
Alkylation
Transferases
Sulfhydryl Compounds
Acetic Acid
Oxidation
Molecules
C-glycoside

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors. / Gervay-Hague, Jacquelyn; Flaherty, Terrence M.; Holmes, Daniel.

In: Tetrahedron, Vol. 53, No. 48, 01.12.1997, p. 16355-16364.

Research output: Contribution to journalArticle

Gervay-Hague, Jacquelyn ; Flaherty, Terrence M. ; Holmes, Daniel. / Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors. In: Tetrahedron. 1997 ; Vol. 53, No. 48. pp. 16355-16364.
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