Studies on the synthesis and bioactivities of substituted dihydropyrazole derivatives

Tian Lin Liu, Sheng Liang Yu, Aiming Yu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A novel and convenient synthetic method for l-phenyl-3-substituted phenyl-4-triazolyldihy-dropyrazoles (1a-1b) and 3-substituted phenyl-4-triazolyldihydropyrazole (7) from α-triazolyl-β-alkoxyacetophenone 4 was described. The reaction condition was studied and optimized. 1, 3, 4, 5-Multi-substituted dihydropyrazole 1c-1h were prepared through the general cyclization of α,β-unsaturated ketone with phenylhydrazine and their structures were confirmed by 1H NMR, MS and elemental analysis. Furthermore, 3,5-substituted dihydropyrazole 6(or 7) reacted with methyl (or ethyl) chloroformate and potassium thiocyanate to afford 1,3,5-(or 4-)substituted dihydropyrazole 2a-2l. The results of preliminary bioassay presented that almost all compounds showed fungicidal, herbicidal and plant growth regulatory activities.

Original languageEnglish (US)
Pages (from-to)232-236
Number of pages5
JournalKao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
Volume19
Issue number2
StatePublished - 1998
Externally publishedYes

Fingerprint

Bioassay
Cyclization
Bioactivity
Ketones
Nuclear magnetic resonance
Derivatives
Chemical analysis
potassium thiocyanate
phenylhydrazine
methyl chloroformate
ethyl chloroformate

Keywords

  • Bioactivity
  • Dihydropyrazole
  • Synthesis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Studies on the synthesis and bioactivities of substituted dihydropyrazole derivatives. / Liu, Tian Lin; Yu, Sheng Liang; Yu, Aiming.

In: Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities, Vol. 19, No. 2, 1998, p. 232-236.

Research output: Contribution to journalArticle

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