Studies on the binding of tetracycline to ribosomes

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Abstract

The binding of tritiated tetracycline to Escherichia coli ribosomes has been investigated by a Millipore filtration technique. The effects of various conditions such as pH, temperature, and ionic strenght on this binding are reported. Apparently no covalent linkage is formed between the drug and the ribosomes. Evidence will be presented that such binding is due to electrostatic interactions between the drug and some component of the ribosome, possibly RNA.

Original languageEnglish (US)
Pages (from-to)506-514
Number of pages9
JournalBBA Section Nucleic Acids And Protein Synthesis
Volume195
Issue number2
StatePublished - Dec 16 1969
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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