Studies on the binding of tetracycline to ribosomes

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The binding of tritiated tetracycline to Escherichia coli ribosomes has been investigated by a Millipore filtration technique. The effects of various conditions such as pH, temperature, and ionic strenght on this binding are reported. Apparently no covalent linkage is formed between the drug and the ribosomes. Evidence will be presented that such binding is due to electrostatic interactions between the drug and some component of the ribosome, possibly RNA.

Original languageEnglish (US)
Pages (from-to)506-514
Number of pages9
JournalBBA Section Nucleic Acids And Protein Synthesis
Volume195
Issue number2
StatePublished - Dec 16 1969
Externally publishedYes

Fingerprint

Tetracycline
Ribosomes
Static Electricity
Drug Interactions
RNA
Escherichia coli
Temperature
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Studies on the binding of tetracycline to ribosomes. / Last, Jerold A.

In: BBA Section Nucleic Acids And Protein Synthesis, Vol. 195, No. 2, 16.12.1969, p. 506-514.

Research output: Contribution to journalArticle

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