Studies on immunity and immunopathogenesis of parrot bornaviral disease in cockatiels

Samer Sadeq Hameed, Jianhua Guo, Ian Tizard, H L Shivaprasad, Susan Payne

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We have demonstrated that vaccination of cockatiels (Nymphicus hollandicus) with killed parrot bornavirus (PaBV) plus recombinant PaBV-4 nucleoprotein (N) in alum was protective against disease in birds challenged with a virulent bornavirus isolate (PaBV-2). Unvaccinated birds, as well as birds vaccinated after challenge, developed gross and histologic lesions typical of proventricular dilatation disease (PDD). There was no evidence that vaccination either before or after challenge made the infection more severe. Birds vaccinated prior to challenge largely remained free of disease, despite the persistence of the virus in many organs. Similar results were obtained when recombinant N, in alum, was used for vaccination. In some rodent models, Borna disease is immune mediated thus we did an additional study whereby cyclosporine A was administered to unvaccinated birds starting 1 day prior to challenge. This treatment also conferred complete protection from disease, but not infection.

Original languageEnglish (US)
Pages (from-to)81-91
Number of pages11
JournalVirology
Volume515
DOIs
StatePublished - Feb 1 2018

Keywords

  • Bornavirus
  • Cockatiel
  • Cyclosporine
  • Proventricular dilatation disease
  • Vaccine

ASJC Scopus subject areas

  • Virology

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