Studies of the chronic inhalation of coal fly ash by rats

Otto G. Raabe, W. S. Tyler, Jerold A Last, L. W. Schwartz, L. O. Lollini, G. L. Fisher, F. D. Wilson, D. L. Dungworth

Research output: Contribution to journalArticle

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Abstract

Respiratory disease-free rats were exposed in two experiments to respirable (mass median aerodynamic diameter MMAD about 2 μm) aerosols of size-classified power plant fly ash at average concentrations of up to 4.2 mg m-3 for 8 h per day for up to 180 consecutive days. The aerosols were characterized with respect to both physical and chemical properties. Immediately after exposure, the animals were evaluated biochemically, morphologically and with other sensitive biological tests to detect effects associated with fly ash inhalation when compared with unexposed controls. Lung burdens of up to 4 mg of ash were found. Macrophages lavaged from lungs of exposed rats were more numerous and yielded more progenitor cell colonies in culture (at the 10% confidence level based on the Mann-Whitney rank-sum test) than from controls. Tracheal mucous glycoprotein secretion was decreased at 7, 50 and 90 days of exposure and increased at 180 days. Clumping of fly ash in cells in the lungs was observed. There were no apparent untoward health effects from inhaled fly ash, since the observed differences between exposed and control rats did not constitute an adverse response.

Original languageEnglish (US)
Pages (from-to)189-211
Number of pages23
JournalAnnals of Occupational Hygiene
Volume26
Issue number1-4
StatePublished - 1982

Fingerprint

Coal Ash
Coal
Inhalation
Rats
Ashes
Aerosols
Lung
Rat control
Power Plants
Pulmonary diseases
Macrophages
Nonparametric Statistics
Chemical properties
Glycoproteins
Aerodynamics
Power plants
Animals
Stem Cells
Physical properties
Health

ASJC Scopus subject areas

  • Health Professions(all)
  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Psychiatry and Mental health

Cite this

Raabe, O. G., Tyler, W. S., Last, J. A., Schwartz, L. W., Lollini, L. O., Fisher, G. L., ... Dungworth, D. L. (1982). Studies of the chronic inhalation of coal fly ash by rats. Annals of Occupational Hygiene, 26(1-4), 189-211.

Studies of the chronic inhalation of coal fly ash by rats. / Raabe, Otto G.; Tyler, W. S.; Last, Jerold A; Schwartz, L. W.; Lollini, L. O.; Fisher, G. L.; Wilson, F. D.; Dungworth, D. L.

In: Annals of Occupational Hygiene, Vol. 26, No. 1-4, 1982, p. 189-211.

Research output: Contribution to journalArticle

Raabe, OG, Tyler, WS, Last, JA, Schwartz, LW, Lollini, LO, Fisher, GL, Wilson, FD & Dungworth, DL 1982, 'Studies of the chronic inhalation of coal fly ash by rats', Annals of Occupational Hygiene, vol. 26, no. 1-4, pp. 189-211.
Raabe OG, Tyler WS, Last JA, Schwartz LW, Lollini LO, Fisher GL et al. Studies of the chronic inhalation of coal fly ash by rats. Annals of Occupational Hygiene. 1982;26(1-4):189-211.
Raabe, Otto G. ; Tyler, W. S. ; Last, Jerold A ; Schwartz, L. W. ; Lollini, L. O. ; Fisher, G. L. ; Wilson, F. D. ; Dungworth, D. L. / Studies of the chronic inhalation of coal fly ash by rats. In: Annals of Occupational Hygiene. 1982 ; Vol. 26, No. 1-4. pp. 189-211.
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