Studies of Rhodamine-123: Effect on rat prostate cancer and human prostate cancer cells in vitro

J. A. Arcadi, K. S. Narayan, G. Techy, C. P. Ng, R. M G Saroufeem, L. W. Jones, T. V. Shankey

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The effect of the lipophilic, cationic dye, Rhodamine-123 (Rh-123), on prostate cancer in rats, and on three tumor cell lines in vitro is reported here. The general toxicity of Rh-123 in mice has been found to be minimal. Lobund-Wistar (L-W) rats with the autochthonous prostate cancer of Pollard were treated for six doses with Rh-123 at a dose of 15 mg/kg subcutaneously every other day. Microscopic examination of the tumors revealed cellular and acinar destruction. The effectiveness of Rh-123 as a cytotoxic agent was tested by clonogenic and viability assays in vitro with three human prostate cancer cell lines. Severe (60-95%) growth inhibition was observed following Rh-123 exposure for 2-5 days at doses as low as 1.6 μg/ml in all three prostate cancer cell lines.

Original languageEnglish (US)
Pages (from-to)86-93
Number of pages8
JournalJournal of Surgical Oncology
Volume59
Issue number2
StatePublished - 1995
Externally publishedYes

Keywords

  • autochthonous rat prostate tumor
  • chemotherapy
  • mitochondrial toxin
  • prostate cancer
  • Rhodamine-123

ASJC Scopus subject areas

  • Surgery
  • Oncology

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