Studies of marginal zinc deprivation in rhesus monkeys. VIII. Effects in early adolescence

M. S. Golub, M. Eric Gershwin, L. S. Hurley, Andrew G Hendrickx

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Arrested adolescent growth and sexual maturation are striking symptoms of severe dietary zinc deprivation. More general implications of mild or marginal Zn deficiency during adolescence are not knwon. Five marginally Zn-deprived (ZD) male monkeys (4 mg Zn/kg diet) were compared with five controls pair fed a diet containing 100 mg Zn/kg during early adolescence. Mean plasma Zn level were 38% lower in ZD group than in controls when evaluations began. During rapid growth plasma Zn decreased in controls but not ZD animals. ZD animals had delayed onset of accelerated weight gain and linear growth; loss of subcutaneous fat typical of early adolescence did not occur. ZD monkeys required two to three times more trials for both learning and reveral a visual discrimination task. Immune function was depressed 20-30% as reflected in early reduced proliferative response of peripheral lymphocytes and later lower immunoglobulin levels. Marginal dietary Zn deprivation affects growth and function in adolescence without producing frank developmental retardation.

Original languageEnglish (US)
Pages (from-to)1046-1051
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume47
Issue number6
StatePublished - 1988

Fingerprint

adolescence
Macaca mulatta
Zinc
zinc
monkeys
Growth
Haplorhini
subcutaneous fat
Diet
Sexual Maturation
diet
immunoglobulins
signs and symptoms (animals and humans)
Subcutaneous Fat
animals
lymphocytes
learning
weight gain
Weight Gain
Immunoglobulins

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Studies of marginal zinc deprivation in rhesus monkeys. VIII. Effects in early adolescence. / Golub, M. S.; Gershwin, M. Eric; Hurley, L. S.; Hendrickx, Andrew G.

In: American Journal of Clinical Nutrition, Vol. 47, No. 6, 1988, p. 1046-1051.

Research output: Contribution to journalArticle

Golub, M. S. ; Gershwin, M. Eric ; Hurley, L. S. ; Hendrickx, Andrew G. / Studies of marginal zinc deprivation in rhesus monkeys. VIII. Effects in early adolescence. In: American Journal of Clinical Nutrition. 1988 ; Vol. 47, No. 6. pp. 1046-1051.
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