Studies of marginal zinc deprivation in rhesus monkeys: VI. Influence on the immunohematology of infants in the first year

D. C. Haynes, M. E. Gershwin, M. S. Golub, A. T. Cheung, L. S. Hurley, A. G. Hendrickx

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Rhesus monkey infants fed a marginally zinc-deficient diet (4 ppm) from conception through 12 mo of postnatal life were monitored for changes in hematological, biochemical, and immunological parameters. These zinc-deprived (ZD) infants were compared to control infants whose mothers were fed a zinc-replete (100 ppm) diet either ad libitum (AL) or pair-fed (PF) throughout gestation and lactation. Blast transformation of peripheral blood lymphocytes to phytohemagglutinin (PHA-P), concanavalin A (Con A), and pokeweed mitogen (PWM), was dramatically depressed in the zinc-deficient (ZD) group. Similarly, ZD infants had reduced polymorphonuclear leukocyte function as measured by chemotaxis to endotoxin-activated plasma and phagocytosis of Candida albicans. Levels of serum IgM were significantly altered in zinc-deficient infants compared to controls. Serum concentrations of IgG and IgA were similar in zinc-deficient and control infants. ZD infants also manifested a hypochromic microcytic anemia at one month of age, reduced activity of the zinc metalloenzyme alkaline phosphatase, and lower activity of SGPT.

Original languageEnglish (US)
Pages (from-to)252-262
Number of pages11
JournalAmerican Journal of Clinical Nutrition
Volume42
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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