Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal effects

J. C. Leek, J. B. Vogler, M. E. Gershwin, M. S. Golub, L. S. Hurley, A. G. Hendrickx

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Skeletal maturation was evaluated in newborn and infant rhesus monkeys that had been subjected to a marginally zinc-deficient diet (4 ppm zinc) from conception through 12 months of postnatal life. Serial radiographic assessment of skeletal development was performed and compared to both ad libitum and pair-fed controls. Radiographs were obtained at birth and at 1, 3, 9, and 12 months of age. In each age group a maturation indicator was selected to identify individuals with abnormal skeletal maturation defined on the basis of presence of epiphyseal ossification centers. Animals were compared only within a given sex group. Additionally, to evaluate endochondral bone mineralization, the appearance of the zone of provisional calcification on the metaphyseal side of the growth plate and the width of the growth plate were assessed. A marginal level of zinc deprivation during gestation and during the 1st yr of life was found to be associated with significantly delayed skeletal maturation and defective mineralization. This abnormality of bone mineralizing has many features similar to human rachitic syndromes and suggests that zinc plays an important role in endochondral bone formation.

Original languageEnglish (US)
Pages (from-to)1203-1212
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume40
Issue number6
StatePublished - 1984

Fingerprint

Macaca mulatta
Zinc
zinc
growth plate
Growth Plate
bone formation
Osteogenesis
rickets
Physiologic Calcification
bone mineralization
Rickets
skeletal development
calcification
mineralization
neonates
Age Groups
bones
Parturition
pregnancy
Newborn Infant

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Leek, J. C., Vogler, J. B., Gershwin, M. E., Golub, M. S., Hurley, L. S., & Hendrickx, A. G. (1984). Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal effects. American Journal of Clinical Nutrition, 40(6), 1203-1212.

Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal effects. / Leek, J. C.; Vogler, J. B.; Gershwin, M. E.; Golub, M. S.; Hurley, L. S.; Hendrickx, A. G.

In: American Journal of Clinical Nutrition, Vol. 40, No. 6, 1984, p. 1203-1212.

Research output: Contribution to journalArticle

Leek, JC, Vogler, JB, Gershwin, ME, Golub, MS, Hurley, LS & Hendrickx, AG 1984, 'Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal effects', American Journal of Clinical Nutrition, vol. 40, no. 6, pp. 1203-1212.
Leek, J. C. ; Vogler, J. B. ; Gershwin, M. E. ; Golub, M. S. ; Hurley, L. S. ; Hendrickx, A. G. / Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal effects. In: American Journal of Clinical Nutrition. 1984 ; Vol. 40, No. 6. pp. 1203-1212.
@article{849e6703dec34b6aa2a1f67b3a95b1e3,
title = "Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal effects",
abstract = "Skeletal maturation was evaluated in newborn and infant rhesus monkeys that had been subjected to a marginally zinc-deficient diet (4 ppm zinc) from conception through 12 months of postnatal life. Serial radiographic assessment of skeletal development was performed and compared to both ad libitum and pair-fed controls. Radiographs were obtained at birth and at 1, 3, 9, and 12 months of age. In each age group a maturation indicator was selected to identify individuals with abnormal skeletal maturation defined on the basis of presence of epiphyseal ossification centers. Animals were compared only within a given sex group. Additionally, to evaluate endochondral bone mineralization, the appearance of the zone of provisional calcification on the metaphyseal side of the growth plate and the width of the growth plate were assessed. A marginal level of zinc deprivation during gestation and during the 1st yr of life was found to be associated with significantly delayed skeletal maturation and defective mineralization. This abnormality of bone mineralizing has many features similar to human rachitic syndromes and suggests that zinc plays an important role in endochondral bone formation.",
author = "Leek, {J. C.} and Vogler, {J. B.} and Gershwin, {M. E.} and Golub, {M. S.} and Hurley, {L. S.} and Hendrickx, {A. G.}",
year = "1984",
language = "English (US)",
volume = "40",
pages = "1203--1212",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "6",

}

TY - JOUR

T1 - Studies of marginal zinc deprivation in rhesus monkeys. V. Fetal and infant skeletal effects

AU - Leek, J. C.

AU - Vogler, J. B.

AU - Gershwin, M. E.

AU - Golub, M. S.

AU - Hurley, L. S.

AU - Hendrickx, A. G.

PY - 1984

Y1 - 1984

N2 - Skeletal maturation was evaluated in newborn and infant rhesus monkeys that had been subjected to a marginally zinc-deficient diet (4 ppm zinc) from conception through 12 months of postnatal life. Serial radiographic assessment of skeletal development was performed and compared to both ad libitum and pair-fed controls. Radiographs were obtained at birth and at 1, 3, 9, and 12 months of age. In each age group a maturation indicator was selected to identify individuals with abnormal skeletal maturation defined on the basis of presence of epiphyseal ossification centers. Animals were compared only within a given sex group. Additionally, to evaluate endochondral bone mineralization, the appearance of the zone of provisional calcification on the metaphyseal side of the growth plate and the width of the growth plate were assessed. A marginal level of zinc deprivation during gestation and during the 1st yr of life was found to be associated with significantly delayed skeletal maturation and defective mineralization. This abnormality of bone mineralizing has many features similar to human rachitic syndromes and suggests that zinc plays an important role in endochondral bone formation.

AB - Skeletal maturation was evaluated in newborn and infant rhesus monkeys that had been subjected to a marginally zinc-deficient diet (4 ppm zinc) from conception through 12 months of postnatal life. Serial radiographic assessment of skeletal development was performed and compared to both ad libitum and pair-fed controls. Radiographs were obtained at birth and at 1, 3, 9, and 12 months of age. In each age group a maturation indicator was selected to identify individuals with abnormal skeletal maturation defined on the basis of presence of epiphyseal ossification centers. Animals were compared only within a given sex group. Additionally, to evaluate endochondral bone mineralization, the appearance of the zone of provisional calcification on the metaphyseal side of the growth plate and the width of the growth plate were assessed. A marginal level of zinc deprivation during gestation and during the 1st yr of life was found to be associated with significantly delayed skeletal maturation and defective mineralization. This abnormality of bone mineralizing has many features similar to human rachitic syndromes and suggests that zinc plays an important role in endochondral bone formation.

UR - http://www.scopus.com/inward/record.url?scp=0021740797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021740797&partnerID=8YFLogxK

M3 - Article

C2 - 6507342

AN - SCOPUS:0021740797

VL - 40

SP - 1203

EP - 1212

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 6

ER -