Studies of marginal zinc deprivation in rhesus monkeys. III. Use of liver biopsy in the assessment of zinc status

Carl L Keen, M. S. Golub, M. Eric Gershwin, B. Lonnerdal, L. S. Hurley

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Studies of marginal zinc deficiency in rhesus monkeys have demonstrated that plasma Zn levels are often a poor indication of Zn status. To better assess the Zn status of these animals, we examined their liver concentration of Zn as well as of other minerals, metallothionein (MT), and superoxide dismutase (SOD). Liver-wedge biopsies were obtained from adult rhesus monkeys fed for 15 mo, either a control (100 μg Zn/g) or a marginally Zn deficient diet (4 μg/g; ZD). Liver Zn and MT concentrations were lower in ZD monkeys than in controls whereas iron concentration was higher in ZD monkeys than in controls. Liver copper, managanese, and magnesium concentrations and activities of CuZnSOD and MnSOD were similar in the two groups. Data from the groups were pooled for regression analysis. Measurement of liver Zn and MT concentrations are useful in the assessment of the effects of long-term Zn deprivation in primates.

Original languageEnglish (US)
Pages (from-to)1041-1045
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Issue number6
StatePublished - 1988


ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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