Studies of marginal zinc deprivation in rhesus monkeys. I. Influence on pregnant dams

M. S. Golub, M. E. Gershwin, L. S. Hurley, D. L. Baly, A. G. Hendrickx

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Rhesus monkeys were fed a diet marginally deficient in zinc (4 ppm zinc) throughout pregnancy and were monitored for changes in hematological, biochemical, and immunological parameters. This dietary zinc level was chosen because it did not produce an overt deficiency syndrome when fed for 10 wk to nonpregnant monkeys. Deprived animals were compared to control groups fed a zinc replete (100 ppm) diet ad libitum or on a food restricted (pair fed) basis. Beginning in the 3rd trimester zinc-deprived monkeys exhibited characteristic signs of deficiency including dermatitis, anorexia, and low levels of plasma zinc (less than 65 μg/100ml) and of serum alkaline phosphatase activity. The extent of plasma zinc depression in deficient monkeys was dependent on total food intake; severely anorexic monkeys lost weight but maintained normal plasma zinc levels; monkeys that gained 20 to 30% of their body weight during pregnancy had severely depressed plasma zinc. Plasma vitamin A was reduced in the deprived group while copper, magnesium, and folate levels remained similar to controls. Hematological changes indicative of iron deficiency anemia (reduced parked cell volume, mean corpuscular volume, and Hb) were also seen in severely deficient monkeys. In addition, the peripheral lymphocyte mitogen response was reduced in deficient dams. We conclude that marginal deficiency of dietary zinc can produce significant abnormalities of nutritional status and has the potential for producing serious immunohematological dysfunction during pregnancy.

Original languageEnglish (US)
Pages (from-to)265-280
Number of pages16
JournalAmerican Journal of Clinical Nutrition
Volume39
Issue number2
StatePublished - 1984

Fingerprint

Macaca mulatta
Zinc
zinc
Haplorhini
monkeys
pregnancy
Pregnancy
Diet
iron deficiency anemia
Erythrocyte Indices
Iron-Deficiency Anemias
Anorexia
Dermatitis
dermatitis
Nutritional Status
Vitamin A
anorexia
Cell Size
Mitogens
Folic Acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Studies of marginal zinc deprivation in rhesus monkeys. I. Influence on pregnant dams. / Golub, M. S.; Gershwin, M. E.; Hurley, L. S.; Baly, D. L.; Hendrickx, A. G.

In: American Journal of Clinical Nutrition, Vol. 39, No. 2, 1984, p. 265-280.

Research output: Contribution to journalArticle

Golub, M. S. ; Gershwin, M. E. ; Hurley, L. S. ; Baly, D. L. ; Hendrickx, A. G. / Studies of marginal zinc deprivation in rhesus monkeys. I. Influence on pregnant dams. In: American Journal of Clinical Nutrition. 1984 ; Vol. 39, No. 2. pp. 265-280.
@article{9f994cff229b4a4e87a5b4440b9f9ced,
title = "Studies of marginal zinc deprivation in rhesus monkeys. I. Influence on pregnant dams",
abstract = "Rhesus monkeys were fed a diet marginally deficient in zinc (4 ppm zinc) throughout pregnancy and were monitored for changes in hematological, biochemical, and immunological parameters. This dietary zinc level was chosen because it did not produce an overt deficiency syndrome when fed for 10 wk to nonpregnant monkeys. Deprived animals were compared to control groups fed a zinc replete (100 ppm) diet ad libitum or on a food restricted (pair fed) basis. Beginning in the 3rd trimester zinc-deprived monkeys exhibited characteristic signs of deficiency including dermatitis, anorexia, and low levels of plasma zinc (less than 65 μg/100ml) and of serum alkaline phosphatase activity. The extent of plasma zinc depression in deficient monkeys was dependent on total food intake; severely anorexic monkeys lost weight but maintained normal plasma zinc levels; monkeys that gained 20 to 30{\%} of their body weight during pregnancy had severely depressed plasma zinc. Plasma vitamin A was reduced in the deprived group while copper, magnesium, and folate levels remained similar to controls. Hematological changes indicative of iron deficiency anemia (reduced parked cell volume, mean corpuscular volume, and Hb) were also seen in severely deficient monkeys. In addition, the peripheral lymphocyte mitogen response was reduced in deficient dams. We conclude that marginal deficiency of dietary zinc can produce significant abnormalities of nutritional status and has the potential for producing serious immunohematological dysfunction during pregnancy.",
author = "Golub, {M. S.} and Gershwin, {M. E.} and Hurley, {L. S.} and Baly, {D. L.} and Hendrickx, {A. G.}",
year = "1984",
language = "English (US)",
volume = "39",
pages = "265--280",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "2",

}

TY - JOUR

T1 - Studies of marginal zinc deprivation in rhesus monkeys. I. Influence on pregnant dams

AU - Golub, M. S.

AU - Gershwin, M. E.

AU - Hurley, L. S.

AU - Baly, D. L.

AU - Hendrickx, A. G.

PY - 1984

Y1 - 1984

N2 - Rhesus monkeys were fed a diet marginally deficient in zinc (4 ppm zinc) throughout pregnancy and were monitored for changes in hematological, biochemical, and immunological parameters. This dietary zinc level was chosen because it did not produce an overt deficiency syndrome when fed for 10 wk to nonpregnant monkeys. Deprived animals were compared to control groups fed a zinc replete (100 ppm) diet ad libitum or on a food restricted (pair fed) basis. Beginning in the 3rd trimester zinc-deprived monkeys exhibited characteristic signs of deficiency including dermatitis, anorexia, and low levels of plasma zinc (less than 65 μg/100ml) and of serum alkaline phosphatase activity. The extent of plasma zinc depression in deficient monkeys was dependent on total food intake; severely anorexic monkeys lost weight but maintained normal plasma zinc levels; monkeys that gained 20 to 30% of their body weight during pregnancy had severely depressed plasma zinc. Plasma vitamin A was reduced in the deprived group while copper, magnesium, and folate levels remained similar to controls. Hematological changes indicative of iron deficiency anemia (reduced parked cell volume, mean corpuscular volume, and Hb) were also seen in severely deficient monkeys. In addition, the peripheral lymphocyte mitogen response was reduced in deficient dams. We conclude that marginal deficiency of dietary zinc can produce significant abnormalities of nutritional status and has the potential for producing serious immunohematological dysfunction during pregnancy.

AB - Rhesus monkeys were fed a diet marginally deficient in zinc (4 ppm zinc) throughout pregnancy and were monitored for changes in hematological, biochemical, and immunological parameters. This dietary zinc level was chosen because it did not produce an overt deficiency syndrome when fed for 10 wk to nonpregnant monkeys. Deprived animals were compared to control groups fed a zinc replete (100 ppm) diet ad libitum or on a food restricted (pair fed) basis. Beginning in the 3rd trimester zinc-deprived monkeys exhibited characteristic signs of deficiency including dermatitis, anorexia, and low levels of plasma zinc (less than 65 μg/100ml) and of serum alkaline phosphatase activity. The extent of plasma zinc depression in deficient monkeys was dependent on total food intake; severely anorexic monkeys lost weight but maintained normal plasma zinc levels; monkeys that gained 20 to 30% of their body weight during pregnancy had severely depressed plasma zinc. Plasma vitamin A was reduced in the deprived group while copper, magnesium, and folate levels remained similar to controls. Hematological changes indicative of iron deficiency anemia (reduced parked cell volume, mean corpuscular volume, and Hb) were also seen in severely deficient monkeys. In addition, the peripheral lymphocyte mitogen response was reduced in deficient dams. We conclude that marginal deficiency of dietary zinc can produce significant abnormalities of nutritional status and has the potential for producing serious immunohematological dysfunction during pregnancy.

UR - http://www.scopus.com/inward/record.url?scp=0021331373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021331373&partnerID=8YFLogxK

M3 - Article

C2 - 6695828

AN - SCOPUS:0021331373

VL - 39

SP - 265

EP - 280

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 2

ER -