Structures and mechanisms in chloride channels

Tsung-Yu Chen, M. F. Tsai, T. C. Hwang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chloride (Cl-) channels are membrane proteins that consist of Cl- permeation pores capable of transporting Cl- ions across lipid membranes. In doing so, they play many important roles in maintaining the physiological functions of various cells, and malfunction of these membrane proteins leads to a variety of hereditary diseases, such as epilepsy, myotonia, and cystic fibrosis. Various types of Cl- channels have been identified with different structures and functions. This chapter discusses the structures and mechanisms of two specific types of Cl- channels - CLC Cl- channels and CFTR Cl- channels. Because homologous molecules of these two types of Cl- channels can function as transporters, the transporter mechanisms related to the functions of Cl- channels are also discussed.

Original languageEnglish (US)
Title of host publicationComprehensive Biophysics
PublisherElsevier Inc.
Pages142-176
Number of pages35
Volume6
ISBN (Print)9780080957180
DOIs
StatePublished - 2012

Keywords

  • ABC transporters
  • ATP
  • CFTR
  • CLC family
  • Gating
  • Membrane transport
  • Permeation
  • Phosphorylation
  • Structure and function
  • Voltage dependence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Chen, T-Y., Tsai, M. F., & Hwang, T. C. (2012). Structures and mechanisms in chloride channels. In Comprehensive Biophysics (Vol. 6, pp. 142-176). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374920-8.00619-6