Structure of the human β-casein encoding gene

Lennart Hansson, Anders Edlund, Thore Johansson, Olle Hernell, Mats Strömqvist, Susanne Lindquist, Bo Lönnerdal, Sven Bergström

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The entire human β-casein-encoding gene, Bca, was cloned and sequenced. The gene consists of eight exons ranging from 21 to 531 nucleotides (nt) in length and extending over 10466 nt. Exon-2 contains the translational start, the entire signal sequence and the codons for the two first amino acids of the mature protein. This corresponds to the organization found in other species. The translational stop is localized to exon-7. Exon/intron boundaries are in accordance with the AG/GT rule and conform to suggested consensus sequences. Splice junctions are located between coding triplets. In all other species analyzed, Bca has been found to consist of nine exons; however, within intron-2 of the human gene, a sequence omitted from human mRNA, but corresponding to exon-3 of other known Bca genes, was revealed.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalGene
Volume139
Issue number2
DOIs
StatePublished - Feb 25 1994

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Keywords

  • exon-skipping
  • Milk protein gene
  • nucleotide sequence
  • recombinant DNA
  • sequence homology

ASJC Scopus subject areas

  • Genetics

Cite this

Hansson, L., Edlund, A., Johansson, T., Hernell, O., Strömqvist, M., Lindquist, S., Lönnerdal, B., & Bergström, S. (1994). Structure of the human β-casein encoding gene. Gene, 139(2), 193-199. https://doi.org/10.1016/0378-1119(94)90754-4