Structure of a human rhinovirus complexed with its receptor molecule

Norman H. Olson, Prasanna R. Kolatkar, Marcos A. Oliveira, R. Holland Cheng, Jeffrey M. Greve, Alan Mcclelland, Timothy S. Baker, Michael G. Rossmann

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

Cryoelectron microscopy has been used to determine the structure of a virus when complexed with its glycoprotein cellular receptor. Human rhinovirus 16 complexed with the two amino-terminal, immunoglobulin-like domains of the intercellular adhesion molecule 1 shows that the intercellular adhesion molecule 1 binds into the 12-Å deep "canyon" on the viral surface. This result confirms the prediction that the viral-receptor attachment site lies in a cavity inaccessible to the host's antibodies. The atomic structures of human rhinovirus 14 and CD4, homologous to human rhinovirus 16 and intercellular adhesion molecule 1, showed excellent correspondence with observed density, thus establishing the virus-receptor interactions.

Original languageEnglish (US)
Pages (from-to)507-511
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number2
StatePublished - Jan 15 1993
Externally publishedYes

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Rhinovirus
Intercellular Adhesion Molecule-1
Virus Receptors
Cryoelectron Microscopy
Viral Structures
Glycoproteins
Antibodies

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Olson, N. H., Kolatkar, P. R., Oliveira, M. A., Cheng, R. H., Greve, J. M., Mcclelland, A., ... Rossmann, M. G. (1993). Structure of a human rhinovirus complexed with its receptor molecule. Proceedings of the National Academy of Sciences of the United States of America, 90(2), 507-511.

Structure of a human rhinovirus complexed with its receptor molecule. / Olson, Norman H.; Kolatkar, Prasanna R.; Oliveira, Marcos A.; Cheng, R. Holland; Greve, Jeffrey M.; Mcclelland, Alan; Baker, Timothy S.; Rossmann, Michael G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 2, 15.01.1993, p. 507-511.

Research output: Contribution to journalArticle

Olson, NH, Kolatkar, PR, Oliveira, MA, Cheng, RH, Greve, JM, Mcclelland, A, Baker, TS & Rossmann, MG 1993, 'Structure of a human rhinovirus complexed with its receptor molecule', Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 2, pp. 507-511.
Olson NH, Kolatkar PR, Oliveira MA, Cheng RH, Greve JM, Mcclelland A et al. Structure of a human rhinovirus complexed with its receptor molecule. Proceedings of the National Academy of Sciences of the United States of America. 1993 Jan 15;90(2):507-511.
Olson, Norman H. ; Kolatkar, Prasanna R. ; Oliveira, Marcos A. ; Cheng, R. Holland ; Greve, Jeffrey M. ; Mcclelland, Alan ; Baker, Timothy S. ; Rossmann, Michael G. / Structure of a human rhinovirus complexed with its receptor molecule. In: Proceedings of the National Academy of Sciences of the United States of America. 1993 ; Vol. 90, No. 2. pp. 507-511.
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