Structure, functions, and evolution of the third complement component and viral molecular mimicry

Arvind Sahu, J. Oriol Sunyer, William T. Moore, Maria Rosa Sarrias, Athena Soulika, John D. Lambris

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The third component of the complement system, C3, is a common denominator in the activation of the classical, alternative, and lectin pathways. The ability of C3 molecule to interact with at least 20 different proteins makes it the most versatile component of this system. Since these interactions are important for phagocytic, immunoregulatory, and immune evasion mechanisms, the analysis of its structure and functions has been a subject of intense research. Here we review our current work on the C3-ligand interactions, C3-related viral molecular mimicry, evolution of the complement system, and identification of C3-based complement inhibitors.

Original languageEnglish (US)
Pages (from-to)109-121
Number of pages13
JournalImmunologic Research
Volume17
Issue number1-2
StatePublished - 1998
Externally publishedYes

Keywords

  • C3
  • Complement
  • Complement inhibitor
  • Compstatin
  • Herpes virus
  • Molecular mimicry
  • Vaccinia virus

ASJC Scopus subject areas

  • Immunology

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    Sahu, A., Sunyer, J. O., Moore, W. T., Sarrias, M. R., Soulika, A., & Lambris, J. D. (1998). Structure, functions, and evolution of the third complement component and viral molecular mimicry. Immunologic Research, 17(1-2), 109-121.