Structure based library approach to photosynthesis inhibitors: The solid phase synthesis of hydro-uracils and thiouracils

Aiming Yu, Hua Zheng Yang, Zhen Pu Zhang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalChinese Chemical Letters
Volume9
Issue number2
StatePublished - 1998
Externally publishedYes

Keywords

  • Hydro-Uracils and Thiouracils
  • Photosynthesis Inhibitors
  • Solid Phase Synthesis

ASJC Scopus subject areas

  • Chemistry(all)

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