Structure based library approach to photosynthesis inhibitors: The solid phase synthesis of hydro-uracils and thiouracils

Aiming Yu; Hua Zheng Yang; Zhen Pu Zhang

Structure based library approach to photosynthesis inhibitors: The solid phase synthesis of hydro-uracils and thiouracils

Aiming Yu, Hua Zheng Yang, Zhen Pu Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.

Original language	English (US)
Pages (from-to)	139-142
Number of pages	4
Journal	Chinese Chemical Letters
Volume	9
Issue number	2
State	Published - 1998
Externally published	Yes

Keywords

Hydro-Uracils and Thiouracils
Photosynthesis Inhibitors
Solid Phase Synthesis

ASJC Scopus subject areas

Chemistry(all)

Fingerprint Dive into the research topics of 'Structure based library approach to photosynthesis inhibitors: The solid phase synthesis of hydro-uracils and thiouracils'. Together they form a unique fingerprint.

Cite this

@article{3ab29d65f73943d99facaa63f410ff01,

title = "Structure based library approach to photosynthesis inhibitors: The solid phase synthesis of hydro-uracils and thiouracils",

abstract = "A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.",

keywords = "Hydro-Uracils and Thiouracils, Photosynthesis Inhibitors, Solid Phase Synthesis",

author = "Aiming Yu and Yang, {Hua Zheng} and Zhang, {Zhen Pu}",

year = "1998",

language = "English (US)",

volume = "9",

pages = "139--142",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Structure based library approach to photosynthesis inhibitors

T2 - The solid phase synthesis of hydro-uracils and thiouracils

AU - Yu, Aiming

AU - Yang, Hua Zheng

AU - Zhang, Zhen Pu

PY - 1998

Y1 - 1998

N2 - A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.

AB - A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.

KW - Hydro-Uracils and Thiouracils

KW - Photosynthesis Inhibitors

KW - Solid Phase Synthesis

UR - http://www.scopus.com/inward/record.url?scp=0032271444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032271444&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032271444

VL - 9

SP - 139

EP - 142

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

SN - 1001-8417

IS - 2

ER -

Structure based library approach to photosynthesis inhibitors: The solid phase synthesis of hydro-uracils and thiouracils

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Cite this