Abstract
A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-142 |
| Number of pages | 4 |
| Journal | Chinese Chemical Letters |
| Volume | 9 |
| Issue number | 2 |
| State | Published - 1998 |
| Externally published | Yes |
Keywords
- Hydro-Uracils and Thiouracils
- Photosynthesis Inhibitors
- Solid Phase Synthesis
ASJC Scopus subject areas
- Chemistry(all)
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Yu, A., Yang, H. Z., & Zhang, Z. P. (1998). Structure based library approach to photosynthesis inhibitors: The solid phase synthesis of hydro-uracils and thiouracils. Chinese Chemical Letters, 9(2), 139-142.