Abstract
A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-142 |
| Number of pages | 4 |
| Journal | Chinese Chemical Letters |
| Volume | 9 |
| Issue number | 2 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Hydro-Uracils and Thiouracils
- Photosynthesis Inhibitors
- Solid Phase Synthesis
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Structure based library approach to photosynthesis inhibitors : The solid phase synthesis of hydro-uracils and thiouracils. / Yu, Aiming; Yang, Hua Zheng; Zhang, Zhen Pu.
In: Chinese Chemical Letters, Vol. 9, No. 2, 1998, p. 139-142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structure based library approach to photosynthesis inhibitors
T2 - The solid phase synthesis of hydro-uracils and thiouracils
AU - Yu, Aiming
AU - Yang, Hua Zheng
AU - Zhang, Zhen Pu
PY - 1998
Y1 - 1998
N2 - A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.
AB - A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.
KW - Hydro-Uracils and Thiouracils
KW - Photosynthesis Inhibitors
KW - Solid Phase Synthesis
UR - http://www.scopus.com/inward/record.url?scp=0032271444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032271444&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0032271444
VL - 9
SP - 139
EP - 142
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
SN - 1001-8417
IS - 2
ER -