Structure and Function of the ThermoTRP Channel Pore

Jie Zheng, Linlin Ma

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Temperature-sensitive transient receptor potential (TRP) channels are structurally similar to other tetrameric cation channels, but can be potently activated by heat. Recent studies suggest that the pore-forming region directly participates in activation gating. In this chapter, we summarize major findings from both structural and functional studies concerning the gating role of the pore region, focusing in particular on TRPV1. The emerging picture is that the peripheral S1-S4 region of TRPV1 is rigid and plays a supporting role for thepore to undergo conformational rearrangements. This places the pore region in the center of activation gating.

Original languageEnglish (US)
Pages (from-to)233-257
Number of pages25
JournalCurrent Topics in Membranes
Volume74
Issue number1
DOIs
StatePublished - 2014

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Keywords

  • Allosteric coupling
  • Conformational rearrangement
  • Structure-function relationship
  • Temperature-sensing

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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