Structural optimization of Zn(II)-activated magnetic resonance imaging probes

Lauren M. Matosziuk, Jonathan H. Leibowitz, Marie Heffern, Keith W. Macrenaris, Mark A. Ratner, Thomas J. Meade

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

We report the structural optimization and mechanistic investigation of a series of bioactivated magnetic resonance imaging contrast agents that transform from low relaxivity to high relaxivity in the presence of Zn(II). The change in relaxivity results from a structural transformation of the complex that alters the coordination environment about the Gd(III) center. Here, we have performed a series of systematic modifications to determine the structure that provides the optimal change in relaxivity in response to the presence of Zn(II). Relaxivity measurements in the presence and absence of Zn(II) were used in conjunction with measurements regarding water access (namely, number of water molecules bound) to the Gd(III) center and temperature-dependent 13C NMR spectroscopy to determine how the coordination environment about the Gd(III) center is affected by the distance between the Zn(II)-binding domain and the Gd(III) chelate, the number of functional groups on the Zn(II)-binding domain, and the presence of Zn(II). The results of this study provide valuable insight into the design principles for future bioactivated magnetic resonance probes.

Original languageEnglish (US)
Pages (from-to)12250-12261
Number of pages12
JournalInorganic Chemistry
Volume52
Issue number21
DOIs
StatePublished - Nov 4 2013
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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