Structural elucidation and synthesis of fritillebinide a from bulbs of Fritillaria ebeiensis

Jizhou Wu; Hanli Ruan; Nianhuan Yao; Handong Sun; C. Morizane; A. Iida; T. Fujitd

Structural elucidation and synthesis of fritillebinide a from bulbs of Fritillaria ebeiensis

Jizhou Wu, Hanli Ruan, Nianhuan Yao, Handong Sun, C. Morizane, A. Iida, T. Fujitd

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To sutdy the non-basic constituents of the Chinese herbal drug "Ebeibeimu", the bulus of Fritillaria ebeiensis G. D. Yu et G. Q. Ji, in order to appraise its quality systematically. METHODS: MeOH extraction and silica gel column chromatography were to isolate pure compound, its structure was determined with various spectral analysis including 2D-NMR techniques and chemical methods. RESULTS: A diterpenoid has been isolated from the EtOAc fraction of the bulus of Fritillaria ebeiensis, growing in the Suizhou disrtict of Hubei province, China. It was established as ent-kauran-16β, 17-acetal ent-16β-kauran-17 (S)-aldehyde (1) on the basis of physicochemical and spectral data and chemical synthesis. CONCLUSION: Compound 1 is a novel acetal diterpenoid dimer with ent-kaurane skeleton, named fritillebinide A.

Original language	English (US)
Pages (from-to)	600-604
Number of pages	5
Journal	Yaoxue Xuebao
Volume	34
Issue number	8
State	Published - Aug 1999
Externally published	Yes

Keywords

Diterpenoid dimer
ent-kaurane
Fritillaria
Fritillaria ebeiensis
Fritillebinide A

ASJC Scopus subject areas

Medicine(all)

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title = "Structural elucidation and synthesis of fritillebinide a from bulbs of Fritillaria ebeiensis",

abstract = "AIM: To sutdy the non-basic constituents of the Chinese herbal drug {"}Ebeibeimu{"}, the bulus of Fritillaria ebeiensis G. D. Yu et G. Q. Ji, in order to appraise its quality systematically. METHODS: MeOH extraction and silica gel column chromatography were to isolate pure compound, its structure was determined with various spectral analysis including 2D-NMR techniques and chemical methods. RESULTS: A diterpenoid has been isolated from the EtOAc fraction of the bulus of Fritillaria ebeiensis, growing in the Suizhou disrtict of Hubei province, China. It was established as ent-kauran-16β, 17-acetal ent-16β-kauran-17 (S)-aldehyde (1) on the basis of physicochemical and spectral data and chemical synthesis. CONCLUSION: Compound 1 is a novel acetal diterpenoid dimer with ent-kaurane skeleton, named fritillebinide A.",

keywords = "Diterpenoid dimer, ent-kaurane, Fritillaria, Fritillaria ebeiensis, Fritillebinide A",

author = "Jizhou Wu and Hanli Ruan and Nianhuan Yao and Handong Sun and C. Morizane and A. Iida and T. Fujitd",

year = "1999",

month = aug,

language = "English (US)",

volume = "34",

pages = "600--604",

journal = "Yao xue xue bao = Acta pharmaceutica Sinica",

issn = "0513-4870",

publisher = "Zhonghua Yixuehui Zazhishe",

number = "8",

}

TY - JOUR

T1 - Structural elucidation and synthesis of fritillebinide a from bulbs of Fritillaria ebeiensis

AU - Wu, Jizhou

AU - Ruan, Hanli

AU - Yao, Nianhuan

AU - Sun, Handong

AU - Morizane, C.

AU - Iida, A.

AU - Fujitd, T.

PY - 1999/8

Y1 - 1999/8

N2 - AIM: To sutdy the non-basic constituents of the Chinese herbal drug "Ebeibeimu", the bulus of Fritillaria ebeiensis G. D. Yu et G. Q. Ji, in order to appraise its quality systematically. METHODS: MeOH extraction and silica gel column chromatography were to isolate pure compound, its structure was determined with various spectral analysis including 2D-NMR techniques and chemical methods. RESULTS: A diterpenoid has been isolated from the EtOAc fraction of the bulus of Fritillaria ebeiensis, growing in the Suizhou disrtict of Hubei province, China. It was established as ent-kauran-16β, 17-acetal ent-16β-kauran-17 (S)-aldehyde (1) on the basis of physicochemical and spectral data and chemical synthesis. CONCLUSION: Compound 1 is a novel acetal diterpenoid dimer with ent-kaurane skeleton, named fritillebinide A.

AB - AIM: To sutdy the non-basic constituents of the Chinese herbal drug "Ebeibeimu", the bulus of Fritillaria ebeiensis G. D. Yu et G. Q. Ji, in order to appraise its quality systematically. METHODS: MeOH extraction and silica gel column chromatography were to isolate pure compound, its structure was determined with various spectral analysis including 2D-NMR techniques and chemical methods. RESULTS: A diterpenoid has been isolated from the EtOAc fraction of the bulus of Fritillaria ebeiensis, growing in the Suizhou disrtict of Hubei province, China. It was established as ent-kauran-16β, 17-acetal ent-16β-kauran-17 (S)-aldehyde (1) on the basis of physicochemical and spectral data and chemical synthesis. CONCLUSION: Compound 1 is a novel acetal diterpenoid dimer with ent-kaurane skeleton, named fritillebinide A.

KW - Diterpenoid dimer

KW - ent-kaurane

KW - Fritillaria

KW - Fritillaria ebeiensis

KW - Fritillebinide A

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