Structural elucidation and synthesis of fritillebinide a from bulbs of Fritillaria ebeiensis

Jizhou Wu, Hanli Ruan, Nianhuan Yao, Handong Sun, C. Morizane, A. Iida, T. Fujitd

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


AIM: To sutdy the non-basic constituents of the Chinese herbal drug "Ebeibeimu", the bulus of Fritillaria ebeiensis G. D. Yu et G. Q. Ji, in order to appraise its quality systematically. METHODS: MeOH extraction and silica gel column chromatography were to isolate pure compound, its structure was determined with various spectral analysis including 2D-NMR techniques and chemical methods. RESULTS: A diterpenoid has been isolated from the EtOAc fraction of the bulus of Fritillaria ebeiensis, growing in the Suizhou disrtict of Hubei province, China. It was established as ent-kauran-16β, 17-acetal ent-16β-kauran-17 (S)-aldehyde (1) on the basis of physicochemical and spectral data and chemical synthesis. CONCLUSION: Compound 1 is a novel acetal diterpenoid dimer with ent-kaurane skeleton, named fritillebinide A.

Original languageEnglish (US)
Pages (from-to)600-604
Number of pages5
JournalYaoxue Xuebao
Issue number8
StatePublished - Aug 1999
Externally publishedYes


  • Diterpenoid dimer
  • ent-kaurane
  • Fritillaria
  • Fritillaria ebeiensis
  • Fritillebinide A

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Structural elucidation and synthesis of fritillebinide a from bulbs of Fritillaria ebeiensis'. Together they form a unique fingerprint.

Cite this