Abstract
AIM: To sutdy the non-basic constituents of the Chinese herbal drug "Ebeibeimu", the bulus of Fritillaria ebeiensis G. D. Yu et G. Q. Ji, in order to appraise its quality systematically. METHODS: MeOH extraction and silica gel column chromatography were to isolate pure compound, its structure was determined with various spectral analysis including 2D-NMR techniques and chemical methods. RESULTS: A diterpenoid has been isolated from the EtOAc fraction of the bulus of Fritillaria ebeiensis, growing in the Suizhou disrtict of Hubei province, China. It was established as ent-kauran-16β, 17-acetal ent-16β-kauran-17 (S)-aldehyde (1) on the basis of physicochemical and spectral data and chemical synthesis. CONCLUSION: Compound 1 is a novel acetal diterpenoid dimer with ent-kaurane skeleton, named fritillebinide A.
Original language | English (US) |
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Pages (from-to) | 600-604 |
Number of pages | 5 |
Journal | Yaoxue Xuebao |
Volume | 34 |
Issue number | 8 |
State | Published - Aug 1999 |
Externally published | Yes |
Keywords
- Diterpenoid dimer
- ent-kaurane
- Fritillaria
- Fritillaria ebeiensis
- Fritillebinide A
ASJC Scopus subject areas
- Medicine(all)