Abstract
During fluid absorption induced by amphotericin B, the lateral intercellular spaces (LIS) of the dog tracheal epithelium were widely dilated as compared to untreated time controls. When fluid absorption was inhibited by ouabain, or by replacement of luminal Na by choline, amphotericin B failed to cause dilation of the LIS. These data suggest that, as in other epithelia, a significant amount of transepithelial fluid flow passes down the LIS, and that these spaces may provide the local osmotic compartment which is responsible for linking transepithelial fluid movement to active ion transport.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 57-69 |
| Number of pages | 13 |
| Journal | Experimental Lung Research |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Molecular Biology
- Clinical Biochemistry
Cite this
Structural changes associated with fluid absorption by dog tracheal epithelium. / Widdicombe, Jonathan; Gashi, A. A.; Basbaum, C. B.; Nathanson, I. T.
In: Experimental Lung Research, Vol. 10, No. 1, 1986, p. 57-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structural changes associated with fluid absorption by dog tracheal epithelium
AU - Widdicombe, Jonathan
AU - Gashi, A. A.
AU - Basbaum, C. B.
AU - Nathanson, I. T.
PY - 1986
Y1 - 1986
N2 - During fluid absorption induced by amphotericin B, the lateral intercellular spaces (LIS) of the dog tracheal epithelium were widely dilated as compared to untreated time controls. When fluid absorption was inhibited by ouabain, or by replacement of luminal Na by choline, amphotericin B failed to cause dilation of the LIS. These data suggest that, as in other epithelia, a significant amount of transepithelial fluid flow passes down the LIS, and that these spaces may provide the local osmotic compartment which is responsible for linking transepithelial fluid movement to active ion transport.
AB - During fluid absorption induced by amphotericin B, the lateral intercellular spaces (LIS) of the dog tracheal epithelium were widely dilated as compared to untreated time controls. When fluid absorption was inhibited by ouabain, or by replacement of luminal Na by choline, amphotericin B failed to cause dilation of the LIS. These data suggest that, as in other epithelia, a significant amount of transepithelial fluid flow passes down the LIS, and that these spaces may provide the local osmotic compartment which is responsible for linking transepithelial fluid movement to active ion transport.
UR - http://www.scopus.com/inward/record.url?scp=0022637780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022637780&partnerID=8YFLogxK
U2 - 10.3109/01902148609057503
DO - 10.3109/01902148609057503
M3 - Article
C2 - 3948811
AN - SCOPUS:0022637780
VL - 10
SP - 57
EP - 69
JO - Experimental Lung Research
JF - Experimental Lung Research
SN - 0190-2148
IS - 1
ER -