Structural basis for on- and off-center responses in retinal bipolar cells

William K. Stell, Andrew T. Ishida, David O. Lightfoot

Research output: Contribution to journalArticle

157 Scopus citations

Abstract

Electron microscopy of Golgi preparations of goldfish retina shows that dendrites of type a (hyperpolarizing, off-center) bipolar cells make wide cleft junctions unassociated with synoptic ribbons, while those of type b (depolarizing, oncenter) bipolar cells make narrow cleft junctions and synoptic ribbon contacts, with rods and cones. This suggests that wide cleft junctions are the site of sign-conserving, and narrow cleft junctions or ribbon contacts (or both) are the site of signinverting synoptic transmission from photoreceptors to bipolars.

Original languageEnglish (US)
Pages (from-to)1269-1271
Number of pages3
JournalScience
Volume198
Issue number4323
StatePublished - 1977

ASJC Scopus subject areas

  • General

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    Stell, W. K., Ishida, A. T., & Lightfoot, D. O. (1977). Structural basis for on- and off-center responses in retinal bipolar cells. Science, 198(4323), 1269-1271.