Structural and mechanistic insights into hepatitis C viral translation initiation

Christopher S. Fraser, Jennifer A. Doudna

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Hepatitis C virus uses an internal ribosome entry site (IRES) to control viral protein synthesis by directly recruiting ribosomes to the translation-start site in the viral mRNA. Structural insights coupled with biochemical studies have revealed that the IRES substitutes for the activities of translation-initiation factors by binding and inducing conformational changes in the 40S ribosomal subunit. Direct interactions of the IRES with initiation factor eIF3 are also crucial for efficient translation initiation, providing clues to the role of eIF3 in protein synthesis.

Original languageEnglish (US)
Pages (from-to)29-38
Number of pages10
JournalNature Reviews Microbiology
Volume5
Issue number1
DOIs
StatePublished - Jan 2007

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Hepatitis C
Peptide Initiation Factors
Eukaryotic Small Ribosome Subunits
Viral Proteins
Ribosomes
Hepacivirus
Messenger RNA
Internal Ribosome Entry Sites
Proteins

ASJC Scopus subject areas

  • Microbiology

Cite this

Structural and mechanistic insights into hepatitis C viral translation initiation. / Fraser, Christopher S.; Doudna, Jennifer A.

In: Nature Reviews Microbiology, Vol. 5, No. 1, 01.2007, p. 29-38.

Research output: Contribution to journalArticle

Fraser, Christopher S. ; Doudna, Jennifer A. / Structural and mechanistic insights into hepatitis C viral translation initiation. In: Nature Reviews Microbiology. 2007 ; Vol. 5, No. 1. pp. 29-38.
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