Abstract
An understanding of the molecular mechanisms which control expression of the type I and III collagen genes may provide a rational basis for the design of more effective therapeutic approaches to fibrotic diseases. The structure of the interstitial collagen genes is reviewed and potential sites which could control their expression are examined. One approach to the study of the regulation of these genes consists in DNA-mediated gene transfection experiments and is discussed in this paper.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 20-33 |
| Number of pages | 14 |
| Journal | Ciba Foundation symposium |
| Volume | 114 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Structural and functional studies on the interstitial collagen genes. / de Crombrugghe, B.; Liau, G.; Setoyama, C.; Schmidt, A.; McKeon, C.; Mudryj, Maria.
In: Ciba Foundation symposium, Vol. 114, 1985, p. 20-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structural and functional studies on the interstitial collagen genes.
AU - de Crombrugghe, B.
AU - Liau, G.
AU - Setoyama, C.
AU - Schmidt, A.
AU - McKeon, C.
AU - Mudryj, Maria
PY - 1985
Y1 - 1985
N2 - An understanding of the molecular mechanisms which control expression of the type I and III collagen genes may provide a rational basis for the design of more effective therapeutic approaches to fibrotic diseases. The structure of the interstitial collagen genes is reviewed and potential sites which could control their expression are examined. One approach to the study of the regulation of these genes consists in DNA-mediated gene transfection experiments and is discussed in this paper.
AB - An understanding of the molecular mechanisms which control expression of the type I and III collagen genes may provide a rational basis for the design of more effective therapeutic approaches to fibrotic diseases. The structure of the interstitial collagen genes is reviewed and potential sites which could control their expression are examined. One approach to the study of the regulation of these genes consists in DNA-mediated gene transfection experiments and is discussed in this paper.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021778638&partnerID=8YFLogxK
M3 - Article
C2 - 2998711
AN - SCOPUS:0021778638
VL - 114
SP - 20
EP - 33
JO - CIBA Foundation Symposia
JF - CIBA Foundation Symposia
SN - 0300-5208
ER -