Abstract
Background and Purpose - Previous studies of cardiovascular risk factors and white matter hyperintensity (WMH) on brain MRI have been limited by the failure to exclude symptomatic cerebrovascular disease and dementia or by the use of semiquantitative rather than quantitative methods to measure WMH volume (WMHV). We examined the relationship between Framingham Stroke Risk Profile (FSRP) and WMHV measured quantitatively in a stroke and dementia-free subset of the Framingham Offspring Cohort. Methods - Brain MRI was performed in 1814 members of the Framingham Offspring Cohort. Pixel-based quantitative measures of WMHV corrected for head size were obtained using a semiautomated algorithm. WMHV was not normally distributed and therefore was log-transformed (LWMHV). The FSRP and its component risk factors measured a mean of 7.5 years before MRI were related to both continuous measures of LWMHV and to the presence of large volumes of LWMHV (LWMHV-large). All analyses were adjusted for age and sex. Results - FSRP was strongly associated with LWMHV and LWMHV-large. Age, smoking, history of cardiovascular disease, hypertension, and left ventricular hypertrophy by electrocardiogram were all significantly related to LWMHV or LWMHV-large. Conclusions - FSRP and several cardiovascular risk factors were related to both WMHV measured continuously and to a categorical designation of large volumes of WMH. These findings provide strong evidence of a vascular basis for WMH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1857-1861 |
| Number of pages | 5 |
| Journal | Stroke |
| Volume | 35 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2004 |
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Keywords
- Cerebrovascular disorders
- Magnetic resonance imaging
- Risk factors
- White matter
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Neuroscience(all)
Cite this
Stroke risk profile predicts white matter hyperintensity volume : The Framingham study. / Jeerakathil, Tom; Wolf, Philip A.; Beiser, Alexa; Massaro, Joseph; Seshadri, Sudha; D'Agostino, Ralph B.; DeCarli, Charles.
In: Stroke, Vol. 35, No. 8, 08.2004, p. 1857-1861.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stroke risk profile predicts white matter hyperintensity volume
T2 - The Framingham study
AU - Jeerakathil, Tom
AU - Wolf, Philip A.
AU - Beiser, Alexa
AU - Massaro, Joseph
AU - Seshadri, Sudha
AU - D'Agostino, Ralph B.
AU - DeCarli, Charles
PY - 2004/8
Y1 - 2004/8
N2 - Background and Purpose - Previous studies of cardiovascular risk factors and white matter hyperintensity (WMH) on brain MRI have been limited by the failure to exclude symptomatic cerebrovascular disease and dementia or by the use of semiquantitative rather than quantitative methods to measure WMH volume (WMHV). We examined the relationship between Framingham Stroke Risk Profile (FSRP) and WMHV measured quantitatively in a stroke and dementia-free subset of the Framingham Offspring Cohort. Methods - Brain MRI was performed in 1814 members of the Framingham Offspring Cohort. Pixel-based quantitative measures of WMHV corrected for head size were obtained using a semiautomated algorithm. WMHV was not normally distributed and therefore was log-transformed (LWMHV). The FSRP and its component risk factors measured a mean of 7.5 years before MRI were related to both continuous measures of LWMHV and to the presence of large volumes of LWMHV (LWMHV-large). All analyses were adjusted for age and sex. Results - FSRP was strongly associated with LWMHV and LWMHV-large. Age, smoking, history of cardiovascular disease, hypertension, and left ventricular hypertrophy by electrocardiogram were all significantly related to LWMHV or LWMHV-large. Conclusions - FSRP and several cardiovascular risk factors were related to both WMHV measured continuously and to a categorical designation of large volumes of WMH. These findings provide strong evidence of a vascular basis for WMH.
AB - Background and Purpose - Previous studies of cardiovascular risk factors and white matter hyperintensity (WMH) on brain MRI have been limited by the failure to exclude symptomatic cerebrovascular disease and dementia or by the use of semiquantitative rather than quantitative methods to measure WMH volume (WMHV). We examined the relationship between Framingham Stroke Risk Profile (FSRP) and WMHV measured quantitatively in a stroke and dementia-free subset of the Framingham Offspring Cohort. Methods - Brain MRI was performed in 1814 members of the Framingham Offspring Cohort. Pixel-based quantitative measures of WMHV corrected for head size were obtained using a semiautomated algorithm. WMHV was not normally distributed and therefore was log-transformed (LWMHV). The FSRP and its component risk factors measured a mean of 7.5 years before MRI were related to both continuous measures of LWMHV and to the presence of large volumes of LWMHV (LWMHV-large). All analyses were adjusted for age and sex. Results - FSRP was strongly associated with LWMHV and LWMHV-large. Age, smoking, history of cardiovascular disease, hypertension, and left ventricular hypertrophy by electrocardiogram were all significantly related to LWMHV or LWMHV-large. Conclusions - FSRP and several cardiovascular risk factors were related to both WMHV measured continuously and to a categorical designation of large volumes of WMH. These findings provide strong evidence of a vascular basis for WMH.
KW - Cerebrovascular disorders
KW - Magnetic resonance imaging
KW - Risk factors
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=3242761581&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3242761581&partnerID=8YFLogxK
U2 - 10.1161/01.STR.0000135226.53499.85
DO - 10.1161/01.STR.0000135226.53499.85
M3 - Article
C2 - 15218158
AN - SCOPUS:3242761581
VL - 35
SP - 1857
EP - 1861
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 8
ER -