Abstract
The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 798-801 |
| Number of pages | 4 |
| Journal | Biochimica et Biophysica Acta - Molecular Basis of Disease |
| Volume | 1842 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
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Keywords
- Cardiovascular
- Disease
- Heart
- Nucleolus
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
Cite this
Stressing on the nucleolus in cardiovascular disease. / Hariharan, Nirmala; Sussman, Mark A.
In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1842, No. 6, 01.01.2014, p. 798-801.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Stressing on the nucleolus in cardiovascular disease
AU - Hariharan, Nirmala
AU - Sussman, Mark A.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
AB - The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
KW - Cardiovascular
KW - Disease
KW - Heart
KW - Nucleolus
UR - http://www.scopus.com/inward/record.url?scp=84897071352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897071352&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2013.09.016
DO - 10.1016/j.bbadis.2013.09.016
M3 - Review article
C2 - 24514103
AN - SCOPUS:84897071352
VL - 1842
SP - 798
EP - 801
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
SN - 0925-4439
IS - 6
ER -