Stressing on the nucleolus in cardiovascular disease

Nirmala Hariharan, Mark A. Sussman

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.

Original languageEnglish (US)
Pages (from-to)798-801
Number of pages4
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1842
Issue number6
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Cardiovascular
  • Disease
  • Heart
  • Nucleolus

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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