Stressing on the nucleolus in cardiovascular disease

Nirmala Hariharan; Mark A. Sussman

doi:10.1016/j.bbadis.2013.09.016

Stressing on the nucleolus in cardiovascular disease

Nirmala Hariharan, Mark A. Sussman

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.

Original language	English (US)
Pages (from-to)	798-801
Number of pages	4
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1842
Issue number	6
DOIs	https://doi.org/10.1016/j.bbadis.2013.09.016
State	Published - Jan 1 2014
Externally published	Yes

Keywords

Cardiovascular
Disease
Heart
Nucleolus

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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title = "Stressing on the nucleolus in cardiovascular disease",

abstract = "The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.",

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AU - Sussman, Mark A.

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AB - The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.

KW - Cardiovascular

KW - Disease

KW - Heart

KW - Nucleolus

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