Stress, sex, and motivated behaviors

Abigail Laman-Maharg, Brian C. Trainor

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Stress is a major risk factor for development of psychiatric disorders such as depression and development of substance use disorder. Although there are important sex differences in the prevalence of these disorders, most preclinical models used to study stress-induced disorders have used males only. Social defeat stress is a commonly used method to induce stress in an ethologically relevant way but has only recently begun to be used in female rodents. Using these new female models, recent studies have examined how social defeat stress affects males and females differently at the behavioral, circuit, and molecular levels. This Mini-Review discusses sex differences in the effects of social defeat stress on social behavior and drug-seeking behavior as well as its impact on the mesolimbic dopamine system and the highly connected region of the bed nucleus of the stria terminalis.

Original languageEnglish (US)
Pages (from-to)83-92
Number of pages10
JournalJournal of Neuroscience Research
Volume95
Issue number1-2
DOIs
StatePublished - Jan 1 2017

Fingerprint

Sexual Behavior
Sex Characteristics
Drug-Seeking Behavior
Septal Nuclei
Social Behavior
Substance-Related Disorders
Psychiatry
Rodentia
Dopamine
Depression

Keywords

  • drug seeking
  • mesolimbic dopamine system
  • social behavior
  • social defeat stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Stress, sex, and motivated behaviors. / Laman-Maharg, Abigail; Trainor, Brian C.

In: Journal of Neuroscience Research, Vol. 95, No. 1-2, 01.01.2017, p. 83-92.

Research output: Contribution to journalReview article

Laman-Maharg, A & Trainor, BC 2017, 'Stress, sex, and motivated behaviors', Journal of Neuroscience Research, vol. 95, no. 1-2, pp. 83-92. https://doi.org/10.1002/jnr.23815
Laman-Maharg, Abigail ; Trainor, Brian C. / Stress, sex, and motivated behaviors. In: Journal of Neuroscience Research. 2017 ; Vol. 95, No. 1-2. pp. 83-92.
@article{473fe5c2d8b747f88317e0193d5e1aff,
title = "Stress, sex, and motivated behaviors",
abstract = "Stress is a major risk factor for development of psychiatric disorders such as depression and development of substance use disorder. Although there are important sex differences in the prevalence of these disorders, most preclinical models used to study stress-induced disorders have used males only. Social defeat stress is a commonly used method to induce stress in an ethologically relevant way but has only recently begun to be used in female rodents. Using these new female models, recent studies have examined how social defeat stress affects males and females differently at the behavioral, circuit, and molecular levels. This Mini-Review discusses sex differences in the effects of social defeat stress on social behavior and drug-seeking behavior as well as its impact on the mesolimbic dopamine system and the highly connected region of the bed nucleus of the stria terminalis.",
keywords = "drug seeking, mesolimbic dopamine system, social behavior, social defeat stress",
author = "Abigail Laman-Maharg and Trainor, {Brian C.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1002/jnr.23815",
language = "English (US)",
volume = "95",
pages = "83--92",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "1-2",

}

TY - JOUR

T1 - Stress, sex, and motivated behaviors

AU - Laman-Maharg, Abigail

AU - Trainor, Brian C.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Stress is a major risk factor for development of psychiatric disorders such as depression and development of substance use disorder. Although there are important sex differences in the prevalence of these disorders, most preclinical models used to study stress-induced disorders have used males only. Social defeat stress is a commonly used method to induce stress in an ethologically relevant way but has only recently begun to be used in female rodents. Using these new female models, recent studies have examined how social defeat stress affects males and females differently at the behavioral, circuit, and molecular levels. This Mini-Review discusses sex differences in the effects of social defeat stress on social behavior and drug-seeking behavior as well as its impact on the mesolimbic dopamine system and the highly connected region of the bed nucleus of the stria terminalis.

AB - Stress is a major risk factor for development of psychiatric disorders such as depression and development of substance use disorder. Although there are important sex differences in the prevalence of these disorders, most preclinical models used to study stress-induced disorders have used males only. Social defeat stress is a commonly used method to induce stress in an ethologically relevant way but has only recently begun to be used in female rodents. Using these new female models, recent studies have examined how social defeat stress affects males and females differently at the behavioral, circuit, and molecular levels. This Mini-Review discusses sex differences in the effects of social defeat stress on social behavior and drug-seeking behavior as well as its impact on the mesolimbic dopamine system and the highly connected region of the bed nucleus of the stria terminalis.

KW - drug seeking

KW - mesolimbic dopamine system

KW - social behavior

KW - social defeat stress

UR - http://www.scopus.com/inward/record.url?scp=84994351448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994351448&partnerID=8YFLogxK

U2 - 10.1002/jnr.23815

DO - 10.1002/jnr.23815

M3 - Review article

VL - 95

SP - 83

EP - 92

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 1-2

ER -