Stress-induced dendritic remodeling in the medial prefrontal cortex: Effects of circuit, hormones and rest

Rebecca M. Shansky, John Morrison

Research output: Contribution to journalShort survey

83 Scopus citations

Abstract

The medial prefrontal cortex (mPFC) has been implicated as a site of dysfunction and abnormal morphology in major depressive disorder and post-traumatic stress disorder, two illnesses that can be brought on by exposure to stress. In animal models, stress has long been shown to induce impairments in tasks known to be mediated by the mPFC, and recent work has demonstrated that chronic stress can lead to morphological changes in mPFC pyramidal cells. This review explores the current literature on stress-induced dendritic remodeling in the mPFC, with particular focus on new findings that illuminate modulators of these effects.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalBrain Research
Volume1293
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Keywords

  • Depression
  • Neuronal plasticity
  • PTSD
  • Restraint stress
  • Sex differences
  • Stress recovery

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

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