Stratus OCT quality control in two multi-centre multiple sclerosis clinical trials

John L Keltner, Kimberly E. Cello, Laura J. Balcer, Peter A. Calabresi, Clyde E. Markowitz, John S Werner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The University of California (UC) Davis Reading Center evaluated 19,961 scans from 981 subjects in two multiple sclerosis therapeutic trials with the aim of determining the influence of optical coherence tomography quality control procedures on error rates. There was no optical coherence tomography technician certification in Trial 1, and technicians had very limited monitoring and feedback during the trial in view of the fact that data were received retrospectively. However, technicians were certified in Trial 2 and submitted data in accordance with the protocol. Trial 2 scans had higher signal strengths, fewer errors, and more useable data than the scans in Trial 1. Thus, certified technicians and prompt transmission of data for ongoing quality control monitoring provided higher quality data in multiple sclerosis trials.

Original languageEnglish (US)
Pages (from-to)57-64
Number of pages8
JournalNeuro-Ophthalmology
Volume35
Issue number2
DOIs
StatePublished - Apr 2011

Keywords

  • Multiple sclerosis
  • neuro-ophthalmology
  • OCT
  • quality control
  • reading centre

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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