Strategies for the development of gadolinium-based 'q'-activatable MRI contrast agents

Chuqiao Tu, Angelique Y. Louie

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The emergence and rapid development of activatable contrast agents (CAs), whose relaxivity changes in response to the variation of a specific marker in the surrounding physiological microenvironment, have expanded the scope of MRI beyond anatomical and functional imaging to also convey information at the cellular and molecular level. The essence of an activatable MRI CA is the difference in relaxivity before and after a change in a physiological variable: the larger the difference, the better the CA. In this review, strategies for the design of activatable gadolinium CAs, with a switching mechanism based on the modulation of hydration (q), sensitive to common variables in the physiological microenvironment, such as pH, light, redox and metal ions, are illustrated and discussed.

Original languageEnglish (US)
Pages (from-to)781-787
Number of pages7
JournalNMR in Biomedicine
Volume26
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • Gadolinium
  • in vivo imaging
  • Luciferase
  • NADH
  • Redox
  • Reversible switching
  • Smart contrast agent
  • Spiropyran

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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