Strategies for functionalizing lipoprotein-based nanoparticles

Sean F. Gilmore, Wei He, Amy Rasley, Nicholas O Fischer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the design and development of nanoparticle platforms for biotechnology and biomedical applications, biocompatibility and functionality are important considerations. In this chapter, we discuss the key characteristics of lipoprotein-based nanoparticles, and how the versatility of their self-Assembly accommodates a wide range of starting components to provide tunable control of size, stability, and functionality. Orthogonal strategies are described to facilitate the incorporation of bioactive cargo molecules (including drugs, nucleic acids, and proteins) for a wide range of applications, ranging from multifunctional vaccine formulations to targeted drug delivery.

Original languageEnglish (US)
Title of host publicationControl of Amphiphile Self-Assembling at the Molecular Level
Subtitle of host publicationSupra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications
EditorsMarc A. Ilies
PublisherAmerican Chemical Society
Pages131-150
Number of pages20
ISBN (Print)9780841232747
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Publication series

NameACS Symposium Series
Volume1271
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

Fingerprint

Lipoproteins
Nanoparticles
Vaccines
Nucleic acids
Biotechnology
Biocompatibility
Self assembly
Nucleic Acids
Proteins
Molecules
Pharmaceutical Preparations
Targeted drug delivery

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Gilmore, S. F., He, W., Rasley, A., & Fischer, N. O. (2017). Strategies for functionalizing lipoprotein-based nanoparticles. In M. A. Ilies (Ed.), Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications (pp. 131-150). (ACS Symposium Series; Vol. 1271). American Chemical Society. https://doi.org/10.1021/bk-2017-1271.ch006

Strategies for functionalizing lipoprotein-based nanoparticles. / Gilmore, Sean F.; He, Wei; Rasley, Amy; Fischer, Nicholas O.

Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. ed. / Marc A. Ilies. American Chemical Society, 2017. p. 131-150 (ACS Symposium Series; Vol. 1271).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gilmore, SF, He, W, Rasley, A & Fischer, NO 2017, Strategies for functionalizing lipoprotein-based nanoparticles. in MA Ilies (ed.), Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. ACS Symposium Series, vol. 1271, American Chemical Society, pp. 131-150. https://doi.org/10.1021/bk-2017-1271.ch006
Gilmore SF, He W, Rasley A, Fischer NO. Strategies for functionalizing lipoprotein-based nanoparticles. In Ilies MA, editor, Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. American Chemical Society. 2017. p. 131-150. (ACS Symposium Series). https://doi.org/10.1021/bk-2017-1271.ch006
Gilmore, Sean F. ; He, Wei ; Rasley, Amy ; Fischer, Nicholas O. / Strategies for functionalizing lipoprotein-based nanoparticles. Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. editor / Marc A. Ilies. American Chemical Society, 2017. pp. 131-150 (ACS Symposium Series).
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