Strategies for enhancement of radioimmunotherapy

Gerald L Denardo, S. DeNardo, D. Kukis, H. Diril, C. Suey, Claude Meares

Research output: Contribution to journalArticle

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Abstract

Two new strategies for increasing tumor uptake have been investigated. First the effect of interleukin-2 (IL-2) on tumor uptake of 125I-Lym-l antibody in nude mice was investigated. Secondly, the use of 67Cu-labeled Lym-1 was evaluated in patients. In nude mice implanted with Raji human lymphoma, a greater than 2-fold enhancement of tumor uptake of 125I-Lym-1 was observed after administration of PEG-interleukin-2 (PEG-IL-2). The macrocycle 1,4,8,11-tetraazacylcotetradecane-N,N′,N′,N'''-tetraacetic acid (TETA), synthesized specifically for copper chelation, has been conjugated to Lym-1 for 67Cu labeling of the monoclonal antibody (MoAb). There was no evidence for bone or normal marrow uptake and the residence time in the tumor was prolonged. Surprisingly, a dose of 4.4 mCi that was intended for imaging induced substantial tumor regression in a patient.

Original languageEnglish (US)
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume18
Issue number6
DOIs
StatePublished - 1991

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Radioimmunotherapy
Neoplasms
Nude Mice
Interleukin-2
Copper
Lymphoma
Bone Marrow
Monoclonal Antibodies
Bone and Bones
Acids
Antibodies

Cite this

Strategies for enhancement of radioimmunotherapy. / Denardo, Gerald L; DeNardo, S.; Kukis, D.; Diril, H.; Suey, C.; Meares, Claude.

In: International Journal of Radiation Applications and Instrumentation., Vol. 18, No. 6, 1991.

Research output: Contribution to journalArticle

Denardo, Gerald L ; DeNardo, S. ; Kukis, D. ; Diril, H. ; Suey, C. ; Meares, Claude. / Strategies for enhancement of radioimmunotherapy. In: International Journal of Radiation Applications and Instrumentation. 1991 ; Vol. 18, No. 6.
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