Abstract
Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-cross-linked counterpart. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive cross-linkers or assembly units makes SCMs responsive to single or multiple stimuli present in tumor local microenvironment or exogenously applied stimuli. In these instances, the payload drug is released almost exclusively in cancerous tissue or cancer cells upon accumulation via enhanced permeability and retention effect or receptor mediated endocytosis. In this review, we highlight recent advances in the development of SCMs for cancer therapy. We also introduce the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 58-73 |
| Number of pages | 16 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 66 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Cross-link
- Drug delivery
- EPR spectroscopy
- FRET
- Micellar nanoparticles
- Stimuli-response
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. / Li, Yuanpei; Xiao, Kai; Zhu, Wei; Deng, Wenbin; Lam, Kit.
In: Advanced Drug Delivery Reviews, Vol. 66, 2014, p. 58-73.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers
AU - Li, Yuanpei
AU - Xiao, Kai
AU - Zhu, Wei
AU - Deng, Wenbin
AU - Lam, Kit
PY - 2014
Y1 - 2014
N2 - Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-cross-linked counterpart. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive cross-linkers or assembly units makes SCMs responsive to single or multiple stimuli present in tumor local microenvironment or exogenously applied stimuli. In these instances, the payload drug is released almost exclusively in cancerous tissue or cancer cells upon accumulation via enhanced permeability and retention effect or receptor mediated endocytosis. In this review, we highlight recent advances in the development of SCMs for cancer therapy. We also introduce the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.
AB - Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-cross-linked counterpart. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive cross-linkers or assembly units makes SCMs responsive to single or multiple stimuli present in tumor local microenvironment or exogenously applied stimuli. In these instances, the payload drug is released almost exclusively in cancerous tissue or cancer cells upon accumulation via enhanced permeability and retention effect or receptor mediated endocytosis. In this review, we highlight recent advances in the development of SCMs for cancer therapy. We also introduce the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.
KW - Cross-link
KW - Drug delivery
KW - EPR spectroscopy
KW - FRET
KW - Micellar nanoparticles
KW - Stimuli-response
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U2 - 10.1016/j.addr.2013.09.008
DO - 10.1016/j.addr.2013.09.008
M3 - Article
VL - 66
SP - 58
EP - 73
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -