Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers

Yuanpei Li, Kai Xiao, Wei Zhu, Wenbin Deng, Kit Lam

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-cross-linked counterpart. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive cross-linkers or assembly units makes SCMs responsive to single or multiple stimuli present in tumor local microenvironment or exogenously applied stimuli. In these instances, the payload drug is released almost exclusively in cancerous tissue or cancer cells upon accumulation via enhanced permeability and retention effect or receptor mediated endocytosis. In this review, we highlight recent advances in the development of SCMs for cancer therapy. We also introduce the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.

Original languageEnglish (US)
Pages (from-to)58-73
Number of pages16
JournalAdvanced Drug Delivery Reviews
Volume66
DOIs
StatePublished - 2014

Fingerprint

Micelles
Pharmaceutical Preparations
Neoplasms
Fluorescence Resonance Energy Transfer
Tumor Microenvironment
Blood Circulation
Electron Spin Resonance Spectroscopy
Drug Delivery Systems
Endocytosis
Blood Proteins
Permeability
Spectrum Analysis

Keywords

  • Cross-link
  • Drug delivery
  • EPR spectroscopy
  • FRET
  • Micellar nanoparticles
  • Stimuli-response

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. / Li, Yuanpei; Xiao, Kai; Zhu, Wei; Deng, Wenbin; Lam, Kit.

In: Advanced Drug Delivery Reviews, Vol. 66, 2014, p. 58-73.

Research output: Contribution to journalArticle

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