Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers

Yuanpei Li, Kai Xiao, Wei Zhu, Wenbin Deng, Kit Lam

Research output: Contribution to journalArticlepeer-review

237 Scopus citations


Stimuli-responsive cross-linked micelles (SCMs) represent an ideal nanocarrier system for drug delivery against cancers. SCMs exhibit superior structural stability compared to their non-cross-linked counterpart. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive cross-linkers or assembly units makes SCMs responsive to single or multiple stimuli present in tumor local microenvironment or exogenously applied stimuli. In these instances, the payload drug is released almost exclusively in cancerous tissue or cancer cells upon accumulation via enhanced permeability and retention effect or receptor mediated endocytosis. In this review, we highlight recent advances in the development of SCMs for cancer therapy. We also introduce the latest biophysical techniques, such as electron paramagnetic resonance (EPR) spectroscopy and fluorescence resonance energy transfer (FRET), for the characterization of the interactions between SCMs and blood proteins.

Original languageEnglish (US)
Pages (from-to)58-73
Number of pages16
JournalAdvanced Drug Delivery Reviews
StatePublished - 2014


  • Cross-link
  • Drug delivery
  • EPR spectroscopy
  • FRET
  • Micellar nanoparticles
  • Stimuli-response

ASJC Scopus subject areas

  • Pharmaceutical Science


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