Stimulatory effect of mevinolin on rat liver phosphatidic acid phosphatase

Ingemar Björkhem, Lars Berglund

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The activity of the soluble form of phosphatidic acid phosphatase in rat liver was stimulated about 2.5-fold by inclusion of mevinolin, a competitive hydroxymethylglutaryl-CoA reductase inhibitor, in the diet (0.1%). The stimulatory effect of mevinolin was present also after dietary addition of cholestyramine (5%) or intraperitoneal administration of ethanol. Addition of cholesterol (2%) to the diet totally abolished the stimulation by mevinolin on phosphatidic acid phosphatase. The results support a correlation between the synthesis of the rate-limiting enzyme in cholesterol biosynthesis and the activity of the apparent rate-limiting enzyme in triacylglycerol biosynthesis.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume920
Issue number1
DOIs
StatePublished - Jul 13 1987
Externally publishedYes

Keywords

  • (Rat liver)
  • Cholesterol synthesis
  • Hydroxymethylglutaryl-CoA reductase
  • Phosphatidic acid phosphatase
  • Triacylglycerol synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Endocrinology

Fingerprint Dive into the research topics of 'Stimulatory effect of mevinolin on rat liver phosphatidic acid phosphatase'. Together they form a unique fingerprint.

  • Cite this