Stimulation of the caudal ventrolateral medulla decreases total lung resistance in dogs

J. C. Connelly, L. W. McCallister, Marc P Kaufman

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Abstract

Although the role played by the caudal ventrolateral medulla in the regulation of the cardiovascular system has been extensively investigated, little is known about the role played by this area in the regulation of airway caliber. Therefore, in α-chloralose-anesthetized dogs, we used both electrical and chemical means to stimulate the caudal ventrolateral medulla while we monitored changes in total lung resistance breath by breath. We found that electrical stimulation (25 μA) of 26 sites in this area significantly decreased total lung resistance from 7.1 ± 0.4 to 5.7 ± 0.3 cmH2O·l-1·s (P < 0.001). The bronchodilation evoked by electrical stimulation was unaffected by β-adrenergic blockade but was abolished by cholinergic blockade. In addition, chemical stimulation of seven sites in the caudal ventrolateral medulla with microinjections of DL-homocysteic acid (0.2 M; 66 nl), which stimulates cell bodies but not fibers of passage, also decreased total lung resistance from 8.3 ± 1.1 to 6.5 ± 0.8 cmH2O·l-1·s (P < 0.01). In contrast, microinjections of DL-homocysteic acid into the nucleus ambiguus (n = 6) increased total lung resistance from 7.5 ± 0.5 to 9.2 ± 0.4 cmH2O·l-1·s (P < 0.05). We conclude that the caudal ventrolateral medulla contains a pool of cell bodies whose excitation causes bronchodilation by withdrawing cholinergic input to airway smooth muscle.

Original languageEnglish (US)
Pages (from-to)912-917
Number of pages6
JournalJournal of Applied Physiology
Volume63
Issue number3
StatePublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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