Stimulation of parabrachial nuclei dilates airways in cats

A. M. Motekaitis, I. C. Solomon, Marc P Kaufman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Stimulation of the parabrachial nuclei has been shown to increase mean arterial pressure as well as to terminate inspiration. Nevertheless, the effect on airway caliber evoked by stimulation of the parabrachial nuclei is not known. Therefore, in chloralose-anesthetized cats, we microinjected DL- homocysteic acid (25 nl; 100 mM) into 44 sites in or near the lateral and medial parabrachial nuclei while calculating breath-by-breath total lung resistance and dynamic compliance. We found that, in 43 of these sites, microinjection of this excitatory amino acid consistently decreased total lung resistance but had no effect on dynamic compliance. The decrease in lung resistance was caused by a withdrawal of cholinergic tone to the airways. We could find no evidence that the decrease in total lung resistance evoked by stimulation of the parabrachial nuclei was caused by activation of either β- adrenergic or nonadrenergic noncholinergic pathways. The decrease in total lung resistance evoked by stimulation of the parabrachial nuclei was not secondary to the baroreceptor reflex even though microinjection frequently increased mean arterial pressure. In addition, microinjection did not have consistent effects on phrenic nerve activity, although in individual circumstances the effect on this activity was quite large. We conclude that stimulation of cell bodies and dendrites in the parabrachial nuclei dilates the airways of anesthetized cats and that the effect is not secondary to the baroreceptor reflex.

Original languageEnglish (US)
Pages (from-to)1712-1718
Number of pages7
JournalJournal of Applied Physiology
Volume76
Issue number4
StatePublished - 1994

Fingerprint

Cats
Microinjections
Lung
Baroreflex
Compliance
Arterial Pressure
Chloralose
Phrenic Nerve
Excitatory Amino Acids
Dendrites
Parabrachial Nucleus
Adrenergic Agents
Cholinergic Agents

Keywords

  • autonomic nervous system
  • cholinergic pathways
  • pneumotaxic center
  • respiration
  • total lung resistance

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Stimulation of parabrachial nuclei dilates airways in cats. / Motekaitis, A. M.; Solomon, I. C.; Kaufman, Marc P.

In: Journal of Applied Physiology, Vol. 76, No. 4, 1994, p. 1712-1718.

Research output: Contribution to journalArticle

Motekaitis, AM, Solomon, IC & Kaufman, MP 1994, 'Stimulation of parabrachial nuclei dilates airways in cats', Journal of Applied Physiology, vol. 76, no. 4, pp. 1712-1718.
Motekaitis, A. M. ; Solomon, I. C. ; Kaufman, Marc P. / Stimulation of parabrachial nuclei dilates airways in cats. In: Journal of Applied Physiology. 1994 ; Vol. 76, No. 4. pp. 1712-1718.
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