Stimulation of intestinal mucosal afferent nerves increases superior mesenteric artery and decreases mesenteric adipose tissue blood flow

F. W. Leung, M. Golub, M. Tuck, I. Yip, Joseph Leung, V. L W Go

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We tested the hypothesis that stimulation of intestinal mucosal afferent nerves produces an increase in superior mesenteric artery (SMA) but a decrease in mesenteric adipose tissue (MAT) blood flow. In anesthetized rats, blood flow in the SMA (pulsed Doppler flowmetry) and MAT (hydrogen gas clearance) was measured simultaneously before and after administration of 0.9% saline, 640 μM capsaicin, or 5% dextrose into the intestinal lumen. The changes in the SMA were 3.8 ± 3.0, 15.9 ± 4.0, and 18.8 ± 7.6%; and those in the MAT, 4.7 ± 4.0, -11.5 ± 3.4, and -0.07 ± 3.4% of baseline, respectively. The data indicate that exposure of the intestinal lumen to an afferent nerve stimulant or nutrient induced a dichotomous pattern of blood flow changes, an increase in the SMA and a reduction in MAT. The capsaicin-sensitive afferent nerves may be instrumental in mediating these energy responses.

Original languageEnglish (US)
Pages (from-to)1217-1222
Number of pages6
JournalDigestive Diseases and Sciences
Volume46
Issue number6
DOIs
StatePublished - 2001

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Keywords

  • Adipose tissue
  • Blood flow
  • Capsaicin
  • Dextrose
  • Hydrogen gas clearance
  • Mesenteric artery
  • Pulse Doppler flowmetry

ASJC Scopus subject areas

  • Gastroenterology

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