Stimulation of H fields of Forel decreases total lung resistance in dogs

L. W. McCallister, J. C. Connelly, Marc P Kaufman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although there is considerable evidence that the H fields of Forel of the posterior diencephalon play an important role in the regulation of cardiovascular function, little is known about the role these areas play in the control of airway caliber. In chloralose-anesthetized paralyzed dogs, we used both electrical and chemical means to stimulate the H fields of Ford, while we monitored breath-by-breath changes in total lung resistance (TLR), a functional index of airway caliber. Electrical stimulation (200-250 μA, 80 Hz, 0.75 ms) of 82 histologically confirmed sites significantly decreased TLR from 9.2 ± 0.4 to 7.9 ± 0.4 cmH2O·l-1·s (P < 0.01). The bronchodilation evoked by electrical stimulation was unaffected by β-adrenergic blockade with propranolol but was abolished by cholinergic blockade with atropine. The increases in airway caliber evoked by stimulation were often accompanied by increases in phrenic nerve activity. Chemical stimulation of 21 of 82 sites with microinjections of DL-homocysteic acid (82 nl, 0.2 and 0.5 M), which stimulates cell bodies but not fibers of passage, also decreased TLR from 8.3 ± 0.5 to 7.3 ± 0.5 cmH2O·l-1·s (P < 0.03). We conclude that stimulation of cell bodies in the H fields of Forel produces bronchodilation by withdrawal of cholinergic tone to airway smooth muscle.

Original languageEnglish (US)
Pages (from-to)2156-2163
Number of pages8
JournalJournal of Applied Physiology
Volume65
Issue number5
StatePublished - 1988
Externally publishedYes

Fingerprint

Dogs
Lung
Cholinergic Agents
Electric Stimulation
Chemical Stimulation
Diencephalon
Chloralose
Phrenic Nerve
Airway Management
Microinjections
Atropine
Propranolol
Adrenergic Agents
Smooth Muscle
Cell Body
homocysteic acid

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Stimulation of H fields of Forel decreases total lung resistance in dogs. / McCallister, L. W.; Connelly, J. C.; Kaufman, Marc P.

In: Journal of Applied Physiology, Vol. 65, No. 5, 1988, p. 2156-2163.

Research output: Contribution to journalArticle

McCallister, L. W. ; Connelly, J. C. ; Kaufman, Marc P. / Stimulation of H fields of Forel decreases total lung resistance in dogs. In: Journal of Applied Physiology. 1988 ; Vol. 65, No. 5. pp. 2156-2163.
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