Stimulation and inhibition of the activity of rat liver cytosolic phosphatidate phosphohydrolase by various phospholipids

E. Humble, Lars Berglund

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The influence of phospholipids on the activity of the soluble phosphatidate phosphohydrolase from rat liver was studied. Phosphatidylethanolamine stimulated the enzyme activity whereas phosphatidylglycerol, phosphatidylserine, and phosphatidylinositol were inhibitory. At a phospholipid concentration of 0.7 mg/ml, phosphatidylglycerol inhibited phosphatidate phosphohydrolase activity by 75%, while the enzyme activity was stimulated twofold in the presence of phosphatidylethanolamine. Both lysophosphatidylglycerol and lysophosphatidylethanolamine inhibited phosphatidate phosphohydrolase activity as did octylglucoside, sodium cholate, and Tween 20. The finding that phospholipids influence hepatic phosphatidate phosphohydrolase activity indicates that changes in the lipid environment may modulate the enzyme activity.

Original languageEnglish (US)
Pages (from-to)1869-1872
Number of pages4
JournalJournal of Lipid Research
Volume32
Issue number11
StatePublished - 1991
Externally publishedYes

Keywords

  • detergents
  • diacylglycerol
  • phosphatidylethanolamine
  • phosphatidylglycerol
  • triacylglycerol

ASJC Scopus subject areas

  • Endocrinology

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