Abstract
Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 711-714 |
| Number of pages | 4 |
| Journal | Annals of Neurology |
| Volume | 28 |
| Issue number | 5 |
| State | Published - Nov 1990 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Stiff-man syndrome : A GABAergic autoimmune disorder with autoantigenic heterogeneity. / Gorin, Fredric A; Baldwin, B.; Tait, R.; Pathak, R.; Seyal, Masud; Mugnaini, E.
In: Annals of Neurology, Vol. 28, No. 5, 11.1990, p. 711-714.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stiff-man syndrome
T2 - A GABAergic autoimmune disorder with autoantigenic heterogeneity
AU - Gorin, Fredric A
AU - Baldwin, B.
AU - Tait, R.
AU - Pathak, R.
AU - Seyal, Masud
AU - Mugnaini, E.
PY - 1990/11
Y1 - 1990/11
N2 - Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.
AB - Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025009438&partnerID=8YFLogxK
M3 - Article
C2 - 2260859
AN - SCOPUS:0025009438
VL - 28
SP - 711
EP - 714
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 5
ER -