Abstract
Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 711-714 |
| Number of pages | 4 |
| Journal | Annals of Neurology |
| Volume | 28 |
| Issue number | 5 |
| State | Published - Nov 1990 |
ASJC Scopus subject areas
- Neuroscience(all)
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Gorin, F. A., Baldwin, B., Tait, R., Pathak, R., Seyal, M., & Mugnaini, E. (1990). Stiff-man syndrome: A GABAergic autoimmune disorder with autoantigenic heterogeneity. Annals of Neurology, 28(5), 711-714.