Stiff-man syndrome: A GABAergic autoimmune disorder with autoantigenic heterogeneity

Fredric A Gorin, B. Baldwin, R. Tait, R. Pathak, Masud Seyal, E. Mugnaini

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.

Original languageEnglish (US)
Pages (from-to)711-714
Number of pages4
JournalAnnals of Neurology
Issue number5
StatePublished - Nov 1990

ASJC Scopus subject areas

  • Neuroscience(all)


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