Abstract
Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.
Original language | English (US) |
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Pages (from-to) | 711-714 |
Number of pages | 4 |
Journal | Annals of Neurology |
Volume | 28 |
Issue number | 5 |
State | Published - Nov 1990 |
ASJC Scopus subject areas
- Neuroscience(all)