Stiff-man syndrome

A GABAergic autoimmune disorder with autoantigenic heterogeneity

Fredric A Gorin, B. Baldwin, R. Tait, R. Pathak, Masud Seyal, E. Mugnaini

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.

Original languageEnglish (US)
Pages (from-to)711-714
Number of pages4
JournalAnnals of Neurology
Volume28
Issue number5
StatePublished - Nov 1990

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Stiff-Person Syndrome
Autoantibodies
Glutamate Decarboxylase
Cerebrospinal Fluid
Glutamic Acid
Presynaptic Terminals
Serum
Type 1 Diabetes Mellitus
gamma-Aminobutyric Acid
Observation
Neurons
Enzymes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stiff-man syndrome : A GABAergic autoimmune disorder with autoantigenic heterogeneity. / Gorin, Fredric A; Baldwin, B.; Tait, R.; Pathak, R.; Seyal, Masud; Mugnaini, E.

In: Annals of Neurology, Vol. 28, No. 5, 11.1990, p. 711-714.

Research output: Contribution to journalArticle

Gorin, FA, Baldwin, B, Tait, R, Pathak, R, Seyal, M & Mugnaini, E 1990, 'Stiff-man syndrome: A GABAergic autoimmune disorder with autoantigenic heterogeneity', Annals of Neurology, vol. 28, no. 5, pp. 711-714.
Gorin, Fredric A ; Baldwin, B. ; Tait, R. ; Pathak, R. ; Seyal, Masud ; Mugnaini, E. / Stiff-man syndrome : A GABAergic autoimmune disorder with autoantigenic heterogeneity. In: Annals of Neurology. 1990 ; Vol. 28, No. 5. pp. 711-714.
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