Steroid-responsive optic neuropathy (SRON) in anti-neutrophil cytoplasmic antibodynegative wegener granulomatosis with false-positive indicators of giant cell arteritis and sarcoidosis

Giao T. Nguyen, John L Keltner

Research output: Contribution to journalArticle

Abstract

A 65-year-old woman with rheumatological symptoms and diplopia was diagnosed as suffering from giant cell arteritis. Four years later she presented to us with a steroid responsive optic neuropathy. A presumptive diagnosis of neurosarcoidosis was made because of a gallium-67 single-photon emission tomography scan indicating a positive 'panda sign'. Subsequent chest computerised tomographic imaging revealed cavitating lung lesions and an open biopsy established the diagnosis of Wegener granulomatosis despite the negative anti-neutrophilic cytoplasmic antibody. At the time of diagnosis the patient had a steroid responsive optic neuropathy and had recently developed a bilateral uveitis. Treatment with cyclophosphamide and corticosteroids produced complete remission with no further progression of disease.

Original languageEnglish (US)
Pages (from-to)363-368
Number of pages6
JournalNeuro-Ophthalmology
Volume34
Issue number5-6
DOIs
StatePublished - Dec 2010

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Keywords

  • Optic neuropathy
  • Steroids
  • Wegener granulomatosis

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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