Steroid hormone concentrations in relation to patient prognosis and prostate tumour grade

M. E. Harper, D. W. Wilson, Hanne M Jensen, C. G. Pierrepoint, K. Griffiths

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Survival of patients who received endocrine therapy as first-line treatment for their prostatic cancer was statistically analysed in relation to several parameters, primary tumour stage, metastatic status, age, pretreatment plasma hormone concentrations and Gleason grade. Prognostic indices were derived for both M0 and M1 patients in which Gleason grade and plasma testosterone concentrations were significant prognostic factors. In the M1 patients growth hormone values were also significant and to a lesser degree age. The relationship of Gleason grade to testosterone, growth hormone, prolactin, the gonadotrophins and age was also analysed. No significant differences in any of these hormones was noted with increasing Gleason grade but the age of patients with Grade 5 tumours was significantly lower.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalJournal of Steroid Biochemistry
Volume27
Issue number1-3
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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