Abstract
Survival of patients who received endocrine therapy as first-line treatment for their prostatic cancer was statistically analysed in relation to several parameters, primary tumour stage, metastatic status, age, pretreatment plasma hormone concentrations and Gleason grade. Prognostic indices were derived for both M0 and M1 patients in which Gleason grade and plasma testosterone concentrations were significant prognostic factors. In the M1 patients growth hormone values were also significant and to a lesser degree age. The relationship of Gleason grade to testosterone, growth hormone, prolactin, the gonadotrophins and age was also analysed. No significant differences in any of these hormones was noted with increasing Gleason grade but the age of patients with Grade 5 tumours was significantly lower.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 521-524 |
| Number of pages | 4 |
| Journal | Journal of Steroid Biochemistry |
| Volume | 27 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology
Cite this
Steroid hormone concentrations in relation to patient prognosis and prostate tumour grade. / Harper, M. E.; Wilson, D. W.; Jensen, Hanne M; Pierrepoint, C. G.; Griffiths, K.
In: Journal of Steroid Biochemistry, Vol. 27, No. 1-3, 1987, p. 521-524.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Steroid hormone concentrations in relation to patient prognosis and prostate tumour grade
AU - Harper, M. E.
AU - Wilson, D. W.
AU - Jensen, Hanne M
AU - Pierrepoint, C. G.
AU - Griffiths, K.
PY - 1987
Y1 - 1987
N2 - Survival of patients who received endocrine therapy as first-line treatment for their prostatic cancer was statistically analysed in relation to several parameters, primary tumour stage, metastatic status, age, pretreatment plasma hormone concentrations and Gleason grade. Prognostic indices were derived for both M0 and M1 patients in which Gleason grade and plasma testosterone concentrations were significant prognostic factors. In the M1 patients growth hormone values were also significant and to a lesser degree age. The relationship of Gleason grade to testosterone, growth hormone, prolactin, the gonadotrophins and age was also analysed. No significant differences in any of these hormones was noted with increasing Gleason grade but the age of patients with Grade 5 tumours was significantly lower.
AB - Survival of patients who received endocrine therapy as first-line treatment for their prostatic cancer was statistically analysed in relation to several parameters, primary tumour stage, metastatic status, age, pretreatment plasma hormone concentrations and Gleason grade. Prognostic indices were derived for both M0 and M1 patients in which Gleason grade and plasma testosterone concentrations were significant prognostic factors. In the M1 patients growth hormone values were also significant and to a lesser degree age. The relationship of Gleason grade to testosterone, growth hormone, prolactin, the gonadotrophins and age was also analysed. No significant differences in any of these hormones was noted with increasing Gleason grade but the age of patients with Grade 5 tumours was significantly lower.
UR - http://www.scopus.com/inward/record.url?scp=0023573211&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023573211&partnerID=8YFLogxK
U2 - 10.1016/0022-4731(87)90349-9
DO - 10.1016/0022-4731(87)90349-9
M3 - Article
C2 - 3121925
AN - SCOPUS:0023573211
VL - 27
SP - 521
EP - 524
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
SN - 0960-0760
IS - 1-3
ER -