Stereotactic radiosurgery for benign meningiomas

Orin Bloch, Gurvinder Kaur, Brian J. Jian, Andrew T. Parsa, Igor J. Barani

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Meningiomas are the second most common primary tumor of the brain. Surgical resection is the preferred treatment for easily accessible tumors that can be safely removed. However, many tumors arise deep within the skull base making complete surgical resection difficult or impossible. Stereotactic radiosurgery is a highly effective alternative to surgical resection that has been used as a primary therapy for benign meningiomas as well as an adjuvant treatment for residual or recurrent tumors. The 5-year tumor control rates for stereotactic radiosurgery are equivalent to gross-total resection with lower morbidity than surgery, especially for skull base lesions. Additionally, adjuvant treatment of subtotally resected tumors results in tumor control rates equivalent to gross-total resection. Stereotactic radiosurgery has been used extensively for the treatment of small and medium sized skull base meningiomas. This technique has also been applied to large meningiomas and superficial tumors such as convexity and parasagittal meningiomas. However, multiple studies demonstrate that tumor control is decreased for superficial lesions and with increasing tumor size. In addition, radiation toxicity increases with increasing tumor size and superficial location. Based on a thorough review of the literature, stereotactic radiosurgery should be considered the primary treatment for skull base meningiomas with high surgical risk and in cases of superficial meningiomas where surgery is contraindicated.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalJournal of Neuro-Oncology
Volume107
Issue number1
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

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Keywords

  • Cyberknife
  • Gamma knife radiosurgery
  • LINAC
  • Meningioma
  • Stereotacic radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Bloch, O., Kaur, G., Jian, B. J., Parsa, A. T., & Barani, I. J. (2012). Stereotactic radiosurgery for benign meningiomas. Journal of Neuro-Oncology, 107(1), 13-20. https://doi.org/10.1007/s11060-011-0720-4