Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field

Relationship with the progression of Alzheimer's disease

Afia Akram, Daniel Christoffel, Anne B. Rocher, Constantin Bouras, Enikö Kövari, Daniel P. Perl, John Morrison, François R. Herrmann, Vahram Haroutunian, Panteleimon Giannakopoulos, Patrick R. Hof

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippocampus and area 9 in 18 elderly individuals with various degrees of cognitive decline. The decrease in spinophilin-immunoreactivity was significantly related to both Braak neurofibrillary tangle (NFT) staging and clinical severity but not Aβ deposition staging. The total number of spinophilin-immunoreactive puncta in CA1 field and area 9 were significantly related to MMSE scores and predicted 23.5 and 61.9% of its variability. The relationship between total number of spinophilin-immunoreactive puncta in CA1 field and MMSE scores did not persist when adjusting for Braak NFT staging. In contrast, the total number of spinophilin-immunoreactive puncta in area 9 was still significantly related to the cognitive outcome explaining an extra 9.6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations.

Original languageEnglish (US)
Pages (from-to)1296-1307
Number of pages12
JournalNeurobiology of Aging
Volume29
Issue number9
DOIs
StatePublished - Sep 1 2008
Externally publishedYes

Fingerprint

Alzheimer Disease
Spine
Dendritic Spines
Neurofibrillary Tangles
Hippocampal CA3 Region
Hippocampal CA1 Region
Dementia
neurabin
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • Cognition
  • Synapses
  • Tangles

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field : Relationship with the progression of Alzheimer's disease. / Akram, Afia; Christoffel, Daniel; Rocher, Anne B.; Bouras, Constantin; Kövari, Enikö; Perl, Daniel P.; Morrison, John; Herrmann, François R.; Haroutunian, Vahram; Giannakopoulos, Panteleimon; Hof, Patrick R.

In: Neurobiology of Aging, Vol. 29, No. 9, 01.09.2008, p. 1296-1307.

Research output: Contribution to journalArticle

Akram, A, Christoffel, D, Rocher, AB, Bouras, C, Kövari, E, Perl, DP, Morrison, J, Herrmann, FR, Haroutunian, V, Giannakopoulos, P & Hof, PR 2008, 'Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: Relationship with the progression of Alzheimer's disease', Neurobiology of Aging, vol. 29, no. 9, pp. 1296-1307. https://doi.org/10.1016/j.neurobiolaging.2007.03.007
Akram, Afia ; Christoffel, Daniel ; Rocher, Anne B. ; Bouras, Constantin ; Kövari, Enikö ; Perl, Daniel P. ; Morrison, John ; Herrmann, François R. ; Haroutunian, Vahram ; Giannakopoulos, Panteleimon ; Hof, Patrick R. / Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field : Relationship with the progression of Alzheimer's disease. In: Neurobiology of Aging. 2008 ; Vol. 29, No. 9. pp. 1296-1307.
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