Stem cell transplantation for enhancement of learning and memory in adult neurocognitive disorders

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The role of adult hippocampal neurogenesis in learning and memory is still incompletely understood. Ablation of neurogenesis with different methods produced equivocal results with respect to working memory in Morris water maze and radial arm maze experiments. Therefore, it is remarkable that in the past few years several investigators have found a positive impact on working memory after adding stem or progenitor cells to the hippocampus in various disease models. The literature on stem cell transplantation for adult neurocognitive disorders is reviewed in this article and attempted to be reconciled with current research on adult hippocampal neurogenesis.

Original languageEnglish (US)
Pages (from-to)60-71
Number of pages12
JournalAging and Disease
Volume1
Issue number1
StatePublished - 2010
Externally publishedYes

Fingerprint

Neurogenesis
Stem Cell Transplantation
Learning
Short-Term Memory
Stem Cells
Hippocampus
Research Personnel
Water
Research
Neurocognitive Disorders

Keywords

  • Aging
  • Alzheimer's disease
  • Learning and memory
  • Neural stem cells
  • Stroke
  • Traumatic brain injury

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cell Biology
  • Clinical Neurology
  • Pathology and Forensic Medicine

Cite this

Stem cell transplantation for enhancement of learning and memory in adult neurocognitive disorders. / Waldau, Ben.

In: Aging and Disease, Vol. 1, No. 1, 2010, p. 60-71.

Research output: Contribution to journalArticle

@article{285dd9ee37a643c784e0e07897363e9e,
title = "Stem cell transplantation for enhancement of learning and memory in adult neurocognitive disorders",
abstract = "The role of adult hippocampal neurogenesis in learning and memory is still incompletely understood. Ablation of neurogenesis with different methods produced equivocal results with respect to working memory in Morris water maze and radial arm maze experiments. Therefore, it is remarkable that in the past few years several investigators have found a positive impact on working memory after adding stem or progenitor cells to the hippocampus in various disease models. The literature on stem cell transplantation for adult neurocognitive disorders is reviewed in this article and attempted to be reconciled with current research on adult hippocampal neurogenesis.",
keywords = "Aging, Alzheimer's disease, Learning and memory, Neural stem cells, Stroke, Traumatic brain injury",
author = "Ben Waldau",
year = "2010",
language = "English (US)",
volume = "1",
pages = "60--71",
journal = "Aging and Disease",
issn = "2152-5250",
publisher = "International Society on Aging and Disease",
number = "1",

}

TY - JOUR

T1 - Stem cell transplantation for enhancement of learning and memory in adult neurocognitive disorders

AU - Waldau, Ben

PY - 2010

Y1 - 2010

N2 - The role of adult hippocampal neurogenesis in learning and memory is still incompletely understood. Ablation of neurogenesis with different methods produced equivocal results with respect to working memory in Morris water maze and radial arm maze experiments. Therefore, it is remarkable that in the past few years several investigators have found a positive impact on working memory after adding stem or progenitor cells to the hippocampus in various disease models. The literature on stem cell transplantation for adult neurocognitive disorders is reviewed in this article and attempted to be reconciled with current research on adult hippocampal neurogenesis.

AB - The role of adult hippocampal neurogenesis in learning and memory is still incompletely understood. Ablation of neurogenesis with different methods produced equivocal results with respect to working memory in Morris water maze and radial arm maze experiments. Therefore, it is remarkable that in the past few years several investigators have found a positive impact on working memory after adding stem or progenitor cells to the hippocampus in various disease models. The literature on stem cell transplantation for adult neurocognitive disorders is reviewed in this article and attempted to be reconciled with current research on adult hippocampal neurogenesis.

KW - Aging

KW - Alzheimer's disease

KW - Learning and memory

KW - Neural stem cells

KW - Stroke

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=84897538025&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897538025&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84897538025

VL - 1

SP - 60

EP - 71

JO - Aging and Disease

JF - Aging and Disease

SN - 2152-5250

IS - 1

ER -